Yoshihisa Hagihara
Overview
Explore the profile of Yoshihisa Hagihara including associated specialties, affiliations and a list of published articles.
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101
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1324
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Recent Articles
1.
Matsuda T, Akazawa-Ogawa Y, Komaba L, Kiyose N, Miyazaki N, Mizuguchi Y, et al.
Front Immunol
. 2024 Jan;
14:1335462.
PMID: 38292485
Antibody maturation is the central function of the adaptive immune response. This process is driven by the repetitive selection of mutations that increase the affinity toward antigens. We hypothesized that...
2.
Kuroda K, Tomita S, Kurashita H, Hatamoto M, Yamaguchi T, Hori T, et al.
Water Res X
. 2023 Sep;
20:100196.
PMID: 37662426
Deciphering unclear microbial interactions is key to improving biological wastewater treatment processes. Microbial predation and parasitism in wastewater treatment ecosystems are unexplored survival strategies that have long been known and...
3.
Sonoi R, Hagihara Y
Pharmacol Res Perspect
. 2022 May;
10(3):e00960.
PMID: 35621230
An understanding of the quantitative relationship between bile canaliculus (BC) dynamics and the disruption of tight junctions (TJs) during drug-induced intrahepatic cholestasis may lead to new strategies aimed at drug...
4.
Shichiri M, Ishida N, Aoki Y, Koike T, Hagihara Y
Free Radic Biol Med
. 2021 Sep;
175:171-183.
PMID: 34474105
Stress induces emotional arousal causing anxiety, irritability, exaggerated startle behaviour, and hypervigilance observed in patients with trauma and stress-related mental disorders, including acute stress disorder and post-traumatic stress disorder. Central...
5.
Sonoi R, Hagihara Y
Biol Open
. 2021 Jun;
10(6).
PMID: 34151938
Entacapone (ENT), a catechol-O-methyltransferase inhibitor, causes liver injury by inducing bile canaliculi (BC) dilation through inhibition of the myosin light kinase pathway. Loss of tight junctions (TJs) induces hepatocyte depolarization,...
6.
Kibria M, Fukutani A, Akazawa-Ogawa Y, Hagihara Y, Kuroda Y
Biomolecules
. 2021 Jun;
11(6).
PMID: 34072518
In this study, we assessed the potential of arginine and lysine solubility-enhancing peptide (SEP) tags to control the solubility of a model protein, anti-EGFR V-7D12, in a thermally denatured state...
7.
Kibria M, Akazawa-Ogawa Y, Hagihara Y, Kuroda Y
Eur J Pharm Biopharm
. 2021 May;
165:13-21.
PMID: 33971271
We previously demonstrated that amorphous aggregates of misfolded V-7D12 antibodies (V-Mis), a potential anti-EGFR drug, can generate a robust serum IgG response. Here we investigate the immunogenic nature, especially the...
8.
Inoue N, Hagihara Y, Wada I
Elife
. 2021 Apr;
10.
PMID: 33871360
To trigger gamete fusion, spermatozoa need to activate the molecular machinery in which sperm IZUMO1 and oocyte JUNO (IZUMO1R) interaction plays a critical role in mammals. Although a set of...
9.
Noji M, Samejima T, Yamaguchi K, So M, Yuzu K, Chatani E, et al.
Commun Biol
. 2021 Jan;
4(1):120.
PMID: 33500517
The thermodynamic hypothesis of protein folding, known as the "Anfinsen's dogma" states that the native structure of a protein represents a free energy minimum determined by the amino acid sequence....
10.
Sonoi R, Hagihara Y
J Biosci Bioeng
. 2020 Sep;
130(6):659-665.
PMID: 32868186
Understanding the fundamental mechanisms that govern the fate of cells during drug-induced intrahepatic cholestasis provides strategies for the establishment of evaluation methods for drug screening. In the present study, the...