Yohan Bignon
Overview
Explore the profile of Yohan Bignon including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
205
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Recent Articles
1.
Mrabti C, Yang N, Desdin-Mico G, Alonso-Calleja A, Vilchez-Acosta A, Pico S, et al.
Res Sq
. 2025 Jan;
PMID: 39764087
Aging is the major risk factor for most human diseases and represents a major socioeconomical challenge for modern societies. Despite its importance, the process of aging remains poorly understood. Epigenetic...
2.
Sakhi I, de Combiens E, Frachon N, Durussel F, Brideau G, Nemazanyy I, et al.
Gene
. 2024 Jul;
928:148766.
PMID: 39019097
Dent disease (DD) is a hereditary renal disorder characterized by low molecular weight (LMW) proteinuria and progressive renal failure. Inactivating mutations of the CLCN5 gene encoding the 2Cl/Hexchanger ClC-5 have...
3.
Bignon Y, Wigger L, Ansermet C, Weger B, Lagarrigue S, Centeno G, et al.
J Clin Invest
. 2023 Mar;
133(8).
PMID: 36862511
Circadian rhythmicity in renal function suggests rhythmic adaptations in renal metabolism. To decipher the role of the circadian clock in renal metabolism, we studied diurnal changes in renal metabolic pathways...
4.
Rinaldi A, Lazareth H, Poindessous V, Nemazanyy I, Sampaio J, Malpetti D, et al.
JCI Insight
. 2022 Aug;
7(18).
PMID: 35998043
Energy metabolism failure in proximal tubule cells (PTCs) is a hallmark of chronic kidney injury. We combined transcriptomic, metabolomic, and lipidomic approaches in experimental models and patient cohorts to investigate...
5.
Hypomagnesemia, Hypocalcemia, and Tubulointerstitial Nephropathy Caused by Claudin-16 Autoantibodies
Figueres L, Bruneau S, Prot-Bertoye C, Brideau G, Neel M, Griveau C, et al.
J Am Soc Nephrol
. 2022 Jun;
33(7):1402-1410.
PMID: 35728884
Background: Chronic hypomagnesemia is commonly due to diarrhea, alcoholism, and drugs. More rarely, it is caused by genetic defects in the effectors of renal magnesium reabsorption. Methods: In an adult...
6.
Ansermet C, Centeno G, Pradervand S, Harmacek D, Garcia A, Daraspe J, et al.
JCI Insight
. 2022 Feb;
7(4).
PMID: 35191396
Peroxisomes are specialized cellular organelles involved in a variety of metabolic processes. In humans, mutations leading to complete loss of peroxisomes cause multiorgan failure (Zellweger's spectrum disorders, ZSD), including renal...
7.
Ansermet C, Centeno G, Bignon Y, Ortiz D, Pradervand S, Garcia A, et al.
Kidney Int
. 2021 Nov;
101(3):563-573.
PMID: 34838539
The circadian clock is a ubiquitous molecular time-keeping mechanism which synchronizes cellular, tissue, and systemic biological functions with 24-hour environmental cycles. Local circadian clocks drive cell type- and tissue-specific rhythms...
8.
Bignon Y, Rinaldi A, Nadour Z, Poindessous V, Nemazanyy I, Lenoir O, et al.
JCI Insight
. 2021 Nov;
7(1).
PMID: 34793337
The biosynthetic routes leading to de novo nicotinamide adenine dinucleotide (NAD+) production are involved in acute kidney injury (AKI), with a critical role for quinolinate phosphoribosyl transferase (QPRT), a bottleneck...
9.
Lazareth H, Poli A, Bignon Y, Mirmiran A, Rabant M, Cohen R, et al.
Kidney Int Rep
. 2021 Jul;
6(7):1904-1911.
PMID: 34307985
Introduction: Givosiran is an RNA interference therapeutic designed to block the synthesis of the aminolevulinic acid (ALA) synthase 1 (ALAS1) enzyme in patients with acute intermittent porphyria (AIP). Givosiran may...
10.
Sakhi I, Bignon Y, Frachon N, Hureaux M, Arevalo B, Gonzalez W, et al.
Hum Mutat
. 2021 Feb;
42(5):537-550.
PMID: 33600050
Mutations in the CLCN5 gene encoding the 2Cl /1H exchanger ClC-5 are associated with Dent disease 1, an inherited renal disorder characterized by low-molecular-weight (LMW) proteinuria and hypercalciuria. In the...