Ivan Nemazanyy
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Explore the profile of Ivan Nemazanyy including associated specialties, affiliations and a list of published articles.
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Articles
73
Citations
1041
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Recent Articles
1.
Andrieu G, Simonin M, Cabannes-Hamy A, Lengline E, Marcais A, Theron A, et al.
Nat Commun
. 2025 Mar;
16(1):2191.
PMID: 40038309
The deregulated activation of the phosphoinositide 3-kinase (PI3K) pathway is a hallmark of aggressive tumors with metabolic plasticity, eliciting their adaptation to the microenvironment and resistance to chemotherapy. A significant...
2.
Musiani D, Yucel H, Vallette M, Angrisani A, El Botty R, Ouine B, et al.
Mol Cell
. 2025 Feb;
PMID: 40010343
Resistance to poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) is the major obstacle to their effectiveness in the treatment of homologous recombination (HR)-deficient (HRD) tumors. Hence, developing alternative treatments for HRD...
3.
Andrieu G, Hypolite G, Latiri M, Balducci E, Costa C, Verhoeyen E, et al.
Blood Adv
. 2024 Nov;
PMID: 39546747
Alterations inactivating the tumor suppressor gene PTEN drive the development of solid and hematological cancers, such as T-cell acute lymphoblastic leukemia (T-ALL), whereby PTEN loss defines poor-prognosis patients. We investigated...
4.
Rinaldi A, Cippa P, Nemazanyy I, Anglicheau D, Pallet N
Transplantation
. 2024 Aug;
108(9):e218-e228.
PMID: 39167563
Background: Taurine is one of the most abundant amino acids in humans. Low taurine levels are associated with cellular senescence, mitochondrial dysfunction, DNA damage, and inflammation in mouse, all of...
5.
Wathieu C, Lavergne A, Xu X, Rolot M, Nemazanyy I, Shostak K, et al.
EMBO J
. 2024 Jul;
43(18):3916-3947.
PMID: 39085648
Intestinal tuft cells are critical for anti-helminth parasite immunity because they produce IL-25, which triggers IL-13 secretion by activated group 2 innate lymphoid cells (ILC2s) to expand both goblet and...
6.
Sakhi I, de Combiens E, Frachon N, Durussel F, Brideau G, Nemazanyy I, et al.
Gene
. 2024 Jul;
928:148766.
PMID: 39019097
Dent disease (DD) is a hereditary renal disorder characterized by low molecular weight (LMW) proteinuria and progressive renal failure. Inactivating mutations of the CLCN5 gene encoding the 2Cl/Hexchanger ClC-5 have...
7.
Zerbib L, Ladraa S, Fraissenon A, Bayard C, Firpion M, Venot Q, et al.
Signal Transduct Target Ther
. 2024 Jun;
9(1):146.
PMID: 38880808
Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK, an endothelial transmembrane receptor signaling through PIK3CA. Venous malformations are associated with pain, bleedings,...
8.
DAria S, Maquet C, Li S, Dhup S, Lepez A, Kohler A, et al.
Proc Natl Acad Sci U S A
. 2024 Mar;
121(13):e2306763121.
PMID: 38498711
Lactate-proton symporter monocarboxylate transporter 1 (MCT1) facilitates lactic acid export from T cells. Here, we report that MCT1 is mandatory for the development of virus-specific CD8 T cell memory. MCT1-deficient...
9.
Tighanimine K, Nabuco Leva Ferreira Freitas J, Nemazanyy I, Bankole A, Benarroch-Popivker D, Brodesser S, et al.
Nat Metab
. 2024 Feb;
6(2):323-342.
PMID: 38409325
Cellular senescence affects many physiological and pathological processes and is characterized by durable cell cycle arrest, an inflammatory secretory phenotype and metabolic reprogramming. Here, by using dynamic transcriptome and metabolome...
10.
Elhage R, Kelly M, Goudin N, Megret J, Legrand A, Nemazanyy I, et al.
Front Immunol
. 2024 Jan;
14:1270268.
PMID: 38288115
Several studies demonstrated that mitochondrial dynamics and metabolic pathways control T cell fate in the periphery. However, little is known about their implication in thymocyte development. Our results showed that...