Yoan Machado
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Explore the profile of Yoan Machado including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
290
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0
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Recent Articles
1.
Grin P, Baid K, de Jesus H, Kozarac N, Bell P, Jiang S, et al.
Cell Rep
. 2024 Dec;
43(12):115080.
PMID: 39673710
SARS-CoV-2 3C-like protease (3CL or M) cleaves the SARS-CoV-2 polyprotein and >300 intracellular host proteins to enhance viral replication. By lytic cell death following gasdermin (GSDM) pore formation in cell...
2.
Cesar Ramos de Jesus H, Solis N, Machado Y, Pablos I, Bell P, Kappelhoff R, et al.
J Virol
. 2024 May;
98(6):e0004924.
PMID: 38742901
SARS-CoV-2 3C-like main protease (3CL) is essential for protein excision from the viral polyprotein. 3CL inhibitor drug development to block SARS-CoV-2 replication focuses on the catalytic non-prime (P) side for...
3.
Pablos I, Machado Y, de Jesus H, Mohamud Y, Kappelhoff R, Lindskog C, et al.
Cell Rep
. 2021 Oct;
37(4):109892.
PMID: 34672947
The main viral protease (3CL) is indispensable for SARS-CoV-2 replication. We delineate the human protein substrate landscape of 3CL by TAILS substrate-targeted N-terminomics. We identify more than 100 substrates in...
4.
Drayton M, Alford M, Pletzer D, Haney E, Machado Y, Luo H, et al.
J Control Release
. 2021 Oct;
339:220-231.
PMID: 34597746
Host defense peptides (HDPs) have been the subject of great interest for the treatment of multidrug-resistant bacterial infections due to their multimodal activity and low induction of resistance. However, aggregation,...
5.
Kamath S, Scheiblhofer S, Johnson C, Machado Y, McLean T, Taki A, et al.
Allergy
. 2020 May;
75(11):2909-2919.
PMID: 32436591
Background: Tropomyosins are highly conserved proteins, an attribute that forms the molecular basis for their IgE antibody cross-reactivity. Despite sequence similarities, their allergenicity varies greatly between ingested and inhaled invertebrate...
6.
Jobin P, Solis N, Machado Y, Bell P, Rai S, Kwon N, et al.
J Biol Chem
. 2019 Nov;
295(8):2186-2202.
PMID: 31771979
Tyrosyl-tRNA synthetase ligates tyrosine to its cognate tRNA in the cytoplasm, but it can also be secreted through a noncanonical pathway. We found that extracellular tyrosyl-tRNA synthetase (YRS) exhibited proinflammatory...
7.
Araujo G, Aglas L, Vaz E, Machado Y, Huber S, Himly M, et al.
Allergy
. 2019 Nov;
75(4):882-891.
PMID: 31750952
Background: Transforming growth factor β1 (TGFβ1) is a cytokine that exerts immunosuppressive functions, as reflected by its ability to induce regulatory T (Treg) cell differentiation and inhibit Th1 and Th2...
8.
Jobin P, Solis N, Machado Y, Bell P, Kwon N, Kim S, et al.
J Biol Chem
. 2019 Jul;
294(35):12866-12879.
PMID: 31324718
Tryptophanyl-tRNA synthetase (WRS) is a cytosolic aminoacyl-tRNA synthetase essential for protein synthesis. WRS is also one of a growing number of intracellular proteins that are attributed distinct noncanonical "moonlighting" functions...
9.
Hill L, Vassiliadi D, Dimopoulou I, Anderson A, Boyle L, Kilgour A, et al.
J Endocrinol
. 2018 Nov;
240(1):27-39.
PMID: 30452386
Corticosteroid-binding globulin (CBG) transports glucocorticoids in blood and is a serine protease inhibitor family member. Human CBG has a reactive center loop (RCL) which, when cleaved by neutrophil elastase (NE),...
10.
Russo V, Klein T, Lim D, Solis N, Machado Y, Hiroyasu S, et al.
Sci Rep
. 2018 Jun;
8(1):9690.
PMID: 29946113
In healthy skin, epidermis and dermis are anchored together at the dermal-epidermal junction (DEJ), a specialized basement membrane pivotal for skin integrity and function. However, increased inflammation in the DEJ...