Ying-Jiun J Chen
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Explore the profile of Ying-Jiun J Chen including associated specialties, affiliations and a list of published articles.
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14
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1361
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Recent Articles
1.
Lee S, Rezzonico M, Friedman B, Huntley M, Meilandt W, Pandey S, et al.
Cell Rep
. 2021 Dec;
37(13):110158.
PMID: 34965428
Non-neuronal responses in neurodegenerative disease have received increasing attention as important contributors to disease pathogenesis and progression. Here we utilize single-cell RNA sequencing to broadly profile 13 cell types in...
2.
Chung J, Goldstein L, Chen Y, Lee J, Webster J, Roose-Girma M, et al.
J Am Soc Nephrol
. 2020 Jul;
31(10):2341-2354.
PMID: 32651223
Background: The glomerulus is a specialized capillary bed that is involved in urine production and BP control. Glomerular injury is a major cause of CKD, which is epidemic and without...
3.
Wu T, Madireddi S, de Almeida P, Banchereau R, Chen Y, Chitre A, et al.
Nature
. 2020 Feb;
579(7798):274-278.
PMID: 32103181
Despite the resounding clinical success in cancer treatment of antibodies that block the interaction of PD1 with its ligand PDL1, the mechanisms involved remain unknown. A major limitation to understanding...
4.
Hsiao Y, Chen Y, Goldstein L, Wu J, Lin Z, Schneider K, et al.
MAbs
. 2020 Feb;
12(1):1722541.
PMID: 32041466
Antibodies from B-cell clonal lineages share sequence and structural properties as well as epitope specificity. Clonally unrelated antibodies can similarly share sequence and specificity properties and are said to be...
5.
Yartseva V, Goldstein L, Rodman J, Kates L, Chen M, Chen Y, et al.
Cell Rep
. 2020 Feb;
30(5):1491-1503.e6.
PMID: 32023464
How satellite cells and their progenitors balance differentiation and self-renewal to achieve sustainable tissue regeneration is not well understood. A major roadblock to understanding satellite cell fate decisions has been...
6.
Suryamohan K, Krishnankutty S, Guillory J, Jevit M, Schroder M, Wu M, et al.
Nat Genet
. 2020 Jan;
52(1):106-117.
PMID: 31907489
Snakebite envenoming is a serious and neglected tropical disease that kills ~100,000 people annually. High-quality, genome-enabled comprehensive characterization of toxin genes will facilitate development of effective humanized recombinant antivenom. We...
7.
Li J, Piskol R, Ybarra R, Chen Y, Li J, Slaga D, et al.
Sci Transl Med
. 2019 Sep;
11(508).
PMID: 31484792
T cell-retargeting therapies have transformed the therapeutic landscape of oncology. Regardless of the modality, T cell activating therapies are commonly accompanied by systemic cytokine release, which can progress to deadly...
8.
Goldstein L, Chen Y, Wu J, Chaudhuri S, Hsiao Y, Schneider K, et al.
Commun Biol
. 2019 Aug;
2:304.
PMID: 31428692
Obtaining full-length antibody heavy- and light-chain variable regions from individual B cells at scale remains a challenging problem. Here we use high-throughput single-cell B-cell receptor sequencing (scBCR-seq) to obtain accurately...
9.
Chen Y, Friedman B, Ha C, Durinck S, Liu J, Rubenstein J, et al.
Sci Rep
. 2017 Apr;
7:45656.
PMID: 28361918
Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. We performed single-cell RNA sequencing on the mouse embryonic medial...
10.
Sun Y, Pasca S, Portmann T, Goold C, Worringer K, Guan W, et al.
Elife
. 2016 Jul;
5.
PMID: 27458797
Dravet Syndrome is an intractable form of childhood epilepsy associated with deleterious mutations in SCN1A, the gene encoding neuronal sodium channel Nav1.1. Earlier studies using human induced pluripotent stem cells...