Yeojin Park
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Explore the profile of Yeojin Park including associated specialties, affiliations and a list of published articles.
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22
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1906
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Recent Articles
11.
Babusis D, Curry M, Kirby B, Park Y, Murakami E, Wang T, et al.
Antimicrob Agents Chemother
. 2018 Feb;
62(5).
PMID: 29439971
Sofosbuvir and ribavirin exert their anti-hepatitis C virus (anti-HCV) activity following metabolic activation in the liver. However, intrahepatic concentrations of the pharmacologically active nucleotide metabolites in humans are poorly characterized...
12.
Lee B, Moon K, Lim J, Park Y, Kim D, Son S, et al.
Oncotarget
. 2017 Dec;
8(53):91481-91493.
PMID: 29207659
Tyrosinase is a key player in ultraviolet-induced melanogenesis. Because excessive melanin accumulation in the skin can induce hyperpigmentation, the development of tyrosinase inhibitors has attracted attention in cosmetic-related fields. However,...
13.
Sheahan T, Sims A, Graham R, Menachery V, Gralinski L, Case J, et al.
Sci Transl Med
. 2017 Jun;
9(396).
PMID: 28659436
Emerging viral infections are difficult to control because heterogeneous members periodically cycle in and out of humans and zoonotic hosts, complicating the development of specific antiviral therapies and vaccines. Coronaviruses...
14.
Kirschberg T, Metobo S, Clarke M, Aktoudianakis V, Babusis D, Barauskas O, et al.
Bioorg Med Chem Lett
. 2017 Mar;
27(8):1840-1847.
PMID: 28274633
A series of 2'-fluorinated C-nucleosides were prepared and tested for anti-HCV activity. Among them, the triphosphate of 2'-fluoro-2'-C-methyl adenosine C-nucleoside (15) was a potent and selective inhibitor of the NS5B...
15.
Stray K, Park Y, Babusis D, Callebaut C, Cihlar T, Ray A, et al.
Antiviral Res
. 2017 Jan;
140:116-120.
PMID: 28131805
HIV-infected patients treated with certain nucleoside reverse transcriptase inhibitors (NRTIs) have experienced adverse effects due to drug-related mitochondrial toxicity. Tenofovir alafenamide (TAF) is a novel prodrug of the NRTI tenofovir...
16.
Warren T, Jordan R, Lo M, Ray A, Mackman R, Soloveva V, et al.
Nature
. 2016 Mar;
531(7594):381-5.
PMID: 26934220
The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for...
17.
Feng J, Xu Y, Barauskas O, Perry J, Ahmadyar S, Stepan G, et al.
Antimicrob Agents Chemother
. 2015 Nov;
60(2):806-17.
PMID: 26596942
Toxicity has emerged during the clinical development of many but not all nucleotide inhibitors (NI) of hepatitis C virus (HCV). To better understand the mechanism for adverse events, clinically relevant...
18.
Murakami E, Wang T, Park Y, Hao J, Lepist E, Babusis D, et al.
Antimicrob Agents Chemother
. 2015 Apr;
59(6):3563-9.
PMID: 25870059
Tenofovir alafenamide (TAF) is a prodrug of tenofovir (TFV) currently in clinical evaluation for treatment for HIV and hepatitis B virus (HBV) infections. Since the target tissue for HBV is...
19.
Kirschberg T, Mish M, Zhang L, Squires N, Wang K, Cho A, et al.
Bioorg Med Chem Lett
. 2015 Feb;
25(5):1040-3.
PMID: 25650256
The first synthesis of 1'-C-CN, 2'-F, 2'-C-Me pyrimidines is described. Anti-HCV activity was assessed and compared to the 1'-C-CN, 2'-C-Me as well as the 2'-F, 2'-C-Me pyrimidines. A phosphoramidate prodrug...
20.
Mish M, Cho A, Kirschberg T, Xu J, Zonte C, Fenaux M, et al.
Bioorg Med Chem Lett
. 2014 Jun;
24(14):3092-5.
PMID: 24907145
The first synthesis of 1'-cyano-2'-C-methyl pyrimidine nucleosides is described. Anti-HCV activity of these nucleosides and their nucleotide phosphoramidate prodrugs was assessed and compared to the 1'-unsubstituted counterparts and to the...