Yasuo Nagafuchi
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Explore the profile of Yasuo Nagafuchi including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Yamada S, Nagafuchi Y, Yamada M, Suzuki H, Natsumoto B, Ota M, et al.
Front Immunol
. 2024 Nov;
15:1475179.
PMID: 39524436
Background: is a negative regulator of T cell activation and one of the key activators of type I interferon (IFN) and NFκB signaling via non-classical pathways. The upstream single nucleotide...
2.
Yoon J, Bae E, Nagafuchi Y, Sudo K, Han J, Park S, et al.
Life Sci Alliance
. 2024 Jul;
7(9).
PMID: 38960622
A pleiotropic immunoregulatory cytokine, TGF-β, signals via the receptor-regulated SMADs: SMAD2 and SMAD3, which are constitutively expressed in normal cells. Here, we show that selective repression of SMAD3 induces cDC...
3.
Izuka S, Komai T, Itamiya T, Ota M, Nagafuchi Y, Shoda H, et al.
Rheumatology (Oxford)
. 2024 Mar;
64(3):1409-1416.
PMID: 38479808
Objective: The objective of this study was to stratify patients with MCTD, based on their immunophenotype. Methods: We analysed the immunophenotype and transcriptome of 24 immune cell subsets [from patients...
4.
Yuuki H, Itamiya T, Nagafuchi Y, Ota M, Fujio K
Front Immunol
. 2024 Feb;
15:1326823.
PMID: 38361948
B cells play a crucial role in the immune response and contribute to various autoimmune diseases. Recent studies have revealed abnormalities in the B cell receptor (BCR) repertoire of patients...
5.
Goto M, Takahashi H, Yoshida R, Itamiya T, Nakano M, Nagafuchi Y, et al.
Sci Immunol
. 2024 Feb;
9(93):eadk1643.
PMID: 38330141
Aging is a significant risk factor for autoimmunity, and many autoimmune diseases tend to onset during adulthood. We conducted an extensive analysis of CD4 T cell subsets from 354 patients...
6.
Inoue M, Nagafuchi Y, Ota M, Tsuchiya H, Tateishi S, Kanda H, et al.
Sci Rep
. 2023 Sep;
13(1):15250.
PMID: 37709837
HLA-DRB1 shared epitope risk alleles are the strongest genetic risk factors for rheumatoid arthritis (RA) and potential biomarkers for treatment response to biological disease-modifying antirheumatic drugs (bDMARDs). This study aimed...
7.
Ota M, Nakano M, Nagafuchi Y, Kobayashi S, Hatano H, Yoshida R, et al.
Ann Rheum Dis
. 2023 Jul;
82(11):1455-1463.
PMID: 37468219
Objectives: Despite the involvement of B cells in the pathogenesis of immune-mediated diseases (IMDs), biological mechanisms underlying their function are scarcely understood. To overcome this gap, here we constructed and...
8.
Yamada S, Nagafuchi Y, Fujio K
Immunol Med
. 2023 Jul;
47(1):12-23.
PMID: 37462450
Early diagnosis and timely therapeutic intervention are clinical challenges of rheumatoid arthritis (RA), especially for treatment-resistant or difficult-to-treat patients. Little is known about the immunological mechanisms involved in refractory RA....
9.
Natsumoto B, Shoda H, Nagafuchi Y, Ota M, Okumura T, Horie Y, et al.
J Autoimmun
. 2023 Jun;
139:103085.
PMID: 37354689
Background: Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by genetic heterogeneity and an interferon (IFN) signature. The overall landscapes of the heritability of SLE remains unclear....
10.
Suwa Y, Nagafuchi Y, Yamada S, Fujio K
Front Immunol
. 2023 May;
14:1161148.
PMID: 37251399
Dendritic cells (DCs) play crucial roles in the pathogenesis of rheumatoid arthritis (RA), a prototypic autoimmune disease characterized by chronic synovitis and joint destruction. Conventional dendritic cells (cDCs) with professional...