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Yasuo Nagafuchi

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Articles 55
Citations 624
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Recent Articles
11.
Nishiwaki A, Komai T, Nagafuchi Y, Tsuchida Y, Shoda H, Fujio K
Int J Rheum Dis . 2023 Mar; 26(8):1635-1639. PMID: 36918366
No abstract available.
12.
Yamada S, Nagafuchi Y, Wang M, Ota M, Hatano H, Takeshima Y, et al.
Ann Rheum Dis . 2023 Mar; 82(6):809-819. PMID: 36918189
Objectives: Little is known about the immunology underlying variable treatment response in rheumatoid arthritis (RA). We performed large-scale transcriptome analyses of peripheral blood immune cell subsets to identify immune cells...
13.
Sugimori Y, Iwasaki Y, Takeshima Y, Okubo M, Kobayashi S, Hatano H, et al.
ACR Open Rheumatol . 2023 Jan; 5(2):93-102. PMID: 36651871
Objective: Idiopathic inflammatory myopathies (IIM) demonstrate characteristic clinical phenotypes depending on the myositis-specific antibody (MSAs) present. We aimed to identify common or MSA-specific immunological pathways in different immune cell types...
14.
Hanata N, Ota M, Tsuchida Y, Nagafuchi Y, Okamura T, Shoda H, et al.
Sci Rep . 2022 Nov; 12(1):18397. PMID: 36319843
Neutrophil extracellular traps (NETs) are involved in systemic lupus erythematosus (SLE). We sought to cluster SLE patients based on serum NET levels. Serum NET levels were higher in SLE patients...
15.
Nagafuchi Y, Ota M, Hatano H, Inoue M, Kobayashi S, Okubo M, et al.
J Autoimmun . 2022 Sep; 133:102907. PMID: 36126366
Objective: Human Leukocyte Antigen (HLA) alleles regulate susceptibility to rheumatoid arthritis (RA) and immune-mediated diseases. This study aims to elucidate the impact of HLA alleles to T cell subsets. Methods:...
16.
Yamaguchi K, Ishigaki K, Suzuki A, Tsuchida Y, Tsuchiya H, Sumitomo S, et al.
Nat Commun . 2022 Aug; 13(1):4659. PMID: 36002455
Splicing quantitative trait loci (sQTLs) are one of the major causal mechanisms in genome-wide association study (GWAS) loci, but their role in disease pathogenesis is poorly understood. One reason is...
17.
Nakano M, Ota M, Takeshima Y, Iwasaki Y, Hatano H, Nagafuchi Y, et al.
Cell . 2022 Aug; 185(18):3375-3389.e21. PMID: 35998627
Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple immune cells. To elucidate SLE pathogenesis, it is essential to understand the dysregulated gene expression pattern linked to various...
18.
Okubo M, Sumitomo S, Tsuchida Y, Nagafuchi Y, Takeshima Y, Yanaoka H, et al.
Arthritis Res Ther . 2022 Aug; 24(1):186. PMID: 35941595
Background: Behçet's syndrome (BS) is an immune-mediated disease characterized by recurrent oral ulcers, genital ulcers, uveitis, and skin symptoms. HLA-B51, as well as other genetic polymorphisms, has been reported to...
19.
Kobayashi S, Nagafuchi Y, Shoda H, Fujio K
Front Immunol . 2022 Jun; 13:900638. PMID: 35686127
Systemic sclerosis (SSc) is an autoimmune disease that is characterized by vascular damage and fibrosis. Both clinical manifestations and immunological disturbances are diverse according to the disease duration. Particularly, changes...
20.
Nagafuchi Y, Yanaoka H, Fujio K
Front Immunol . 2022 Jun; 13:857269. PMID: 35663941
Various immune cell types, including monocytes, macrophages, and adaptive immune T and B cells, play major roles in inflammation in systemic autoimmune diseases. However, the precise contribution of these cells...