Mineto Ota
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Explore the profile of Mineto Ota including associated specialties, affiliations and a list of published articles.
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44
Citations
410
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Recent Articles
1.
Spence J, Mostafavi H, Ota M, Milind N, Gjorgjieva T, Smith C, et al.
bioRxiv
. 2025 Feb;
PMID: 39935885
Standard genome-wide association studies (GWAS) and rare variant burden tests are essential tools for identifying trait-relevant genes. Although these methods are conceptually similar, we show by analyzing association studies of...
2.
Ota M, Spence J, Zeng T, Dann E, Marson A, Pritchard J
bioRxiv
. 2025 Feb;
PMID: 39896538
Genetic association studies provide a unique tool for identifying causal links from genes to human traits and diseases. However, it is challenging to determine the biological mechanisms underlying most associations,...
3.
Akutsu Y, Ota M, Itamiya T, Mori M, Morio T, Yamamoto K, et al.
J Autoimmun
. 2025 Jan;
150():103355.
PMID: 39787676
It has been known that Epstein-Barr virus (EBV) can latently infect immune cells after the initial infection, and epidemiological studies have suggested its association with the onset of immune-mediated diseases...
4.
Arce M, Umhoefer J, Arang N, Kasinathan S, Freimer J, Steinhart Z, et al.
Nature
. 2024 Dec;
637(8047):930-939.
PMID: 39663454
The ability of cells to maintain distinct identities and respond to transient environmental signals requires tightly controlled regulation of gene networks. These dynamic regulatory circuits that respond to extracellular cues...
5.
Yamada S, Nagafuchi Y, Yamada M, Suzuki H, Natsumoto B, Ota M, et al.
Front Immunol
. 2024 Nov;
15:1475179.
PMID: 39524436
Background: is a negative regulator of T cell activation and one of the key activators of type I interferon (IFN) and NFκB signaling via non-classical pathways. The upstream single nucleotide...
6.
Fujio K, Ushijima T, Okamura T, Ota M
Int Immunol
. 2024 Nov;
37(4):189-194.
PMID: 39514642
In systemic lupus erythematosus (SLE), the production of autoantibodies is a crucial characteristic, and B cells play a significant role in its pathogenesis. B cells are the immune cells most...
7.
Weinstock J, Arce M, Freimer J, Ota M, Marson A, Battle A, et al.
Cell Genom
. 2024 Oct;
4(11):100671.
PMID: 39395408
The effects of genetic variation on complex traits act mainly through changes in gene regulation. Although many genetic variants have been linked to target genes in cis, the trans-regulatory cascade...
8.
Umhoefer J, Arce M, Whalen S, Dajani R, Goudy L, Kasinathan S, et al.
bioRxiv
. 2024 Sep;
PMID: 39282425
FOXP3 is a lineage-defining transcription factor (TF) for immune-suppressive regulatory T cells (Tregs). While mice exclusively express FOXP3 in Tregs, humans also transiently express FOXP3 in stimulated conventional CD4+ T...
9.
Sumida T, Lincoln M, He L, Park Y, Ota M, Oguchi A, et al.
Sci Transl Med
. 2024 Aug;
16(762):eadp1720.
PMID: 39196959
Autoimmune diseases, among the most common disorders of young adults, are mediated by genetic and environmental factors. Although CD4FOXP3 regulatory T cells (T) play a central role in preventing autoimmunity,...
10.
Izuka S, Umezawa N, Komai T, Sugimori Y, Kimura N, Mizoguchi F, et al.
Arthritis Rheumatol
. 2024 Aug;
77(1):99-106.
PMID: 39162115
Objective: We aim to investigate transcriptomic and immunophenotypic features of muscle specimens from patients with idiopathic inflammatory myopathy (IIM). Methods: Bulk RNA-sequencing was performed on muscle biopsy samples from 16...