Yasumitsu Nagao
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Explore the profile of Yasumitsu Nagao including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
358
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Recent Articles
1.
Togashi T, Baatartsogt N, Nagao Y, Kashiwakura Y, Hayakawa M, Hiramoto T, et al.
Arterioscler Thromb Vasc Biol
. 2024 Nov;
44(12):2616-2627.
PMID: 39508105
Background: PC (protein C) is a plasma anticoagulant encoded by ; mutation in both alleles results in neonatal purpura fulminans-a fatal systemic thrombotic disorder. In the present study, we aimed...
2.
Tominaga K, Sakashita E, Kasashima K, Kuroiwa K, Nagao Y, Iwamori N, et al.
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36768434
Epigenetic regulation via epigenetic factors in collaboration with tissue-specific transcription factors is curtail for establishing functional organ systems during development. Brain development is tightly regulated by epigenetic factors, which are...
3.
Byambaa S, Uosaki H, Hara H, Nagao Y, Abe T, Shibata H, et al.
Exp Anim
. 2019 Dec;
69(2):189-198.
PMID: 31801915
X-linked severe combined immunodeficiency (X-SCID) is an inherited genetic disorder. A majority of X-SCID subjects carries point mutations in the Interleukin-2 receptor gamma chain (IL2RG) gene. In contrast, Il2rg-knockout mice...
4.
Ohmori T, Nagao Y, Mizukami H, Sakata A, Muramatsu S, Ozawa K, et al.
Sci Rep
. 2017 Jun;
7(1):4159.
PMID: 28646206
Haemophilia B, a congenital haemorrhagic disease caused by mutations in coagulation factor IX gene (F9), is considered an appropriate target for genome editing technology. Here, we describe treatment strategies for...
5.
Kawata H, Kamiakito T, Nakaya T, Komatsubara M, Komatsu K, Morita T, et al.
J Steroid Biochem Mol Biol
. 2016 Jun;
165(Pt B):219-227.
PMID: 27329245
Endocrine resistance is a major problem in prostate cancer. Recent studies suggest that cellular plasticity plays a key role in therapy resistance. Yet little is known about the cellular changes...
6.
Horii T, Yamamoto M, Morita S, Kimura M, Nagao Y, Hatada I
Sci Rep
. 2015 Mar;
5:8907.
PMID: 25752699
Mammalian tetraploid embryos die in early development because of defects in the epiblast. Experiments with diploid/tetraploid chimeric mice, obtained via the aggregation of embryonic stem cells, clarified that while tetraploid...
7.
Yamamoto S, Nagao Y, Kuroiwa K, Hakamata Y, Ichida M, Saito-Ohara F, et al.
Transgenic Res
. 2014 Jul;
23(5):757-65.
PMID: 25008421
We developed a transgenic mouse line with Y chromosome-linked green fluorescent protein expressing transgenes (Y-GFP) by the conventional microinjection into the pronucleus of C57BL/6J fertilized oocytes. Embryonic stem (ES) cells...
8.
Kasashima K, Nagao Y, Endo H
Reprod Med Biol
. 2014 Feb;
13:11-20.
PMID: 24482608
Mitochondria play a crucial role in the development and function of germ cells. Mitochondria contain a maternally inherited genome that should be transmitted to offspring without reactive oxygen species-induced damage...
9.
Horii T, Suetake I, Yanagisawa E, Morita S, Kimura M, Nagao Y, et al.
J Reprod Dev
. 2011 Jun;
57(5):579-85.
PMID: 21666347
Manipulation of preimplantation embryos in vitro, such as in vitro fertilization (IVF), in vitro culture (IVC), intracytoplasmic sperm injection (ICSI), somatic cell nuclear transfer (SCNT) and other assisted reproduction technologies...
10.
Horii T, Kimura M, Morita S, Nagao Y, Hatada I
Stem Cells
. 2007 Oct;
26(1):79-88.
PMID: 17962706
In mammals, complementary contributions of both the maternal and the paternal genomes are required for normal development because of the parental-allele-specific modification of the genome, called genomic imprinting. Therefore, parthenogenetic...