Hiromichi Yonekawa
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Explore the profile of Hiromichi Yonekawa including associated specialties, affiliations and a list of published articles.
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100
Citations
2943
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Recent Articles
1.
Li Y, Fujiwara K, Osada N, Kawai Y, Takada T, Kryukov A, et al.
Heredity (Edinb)
. 2020 Sep;
126(1):132-147.
PMID: 32934361
The Eurasian house mouse Mus musculus is useful for tracing prehistorical human movement related to the spread of farming. We determined whole mitochondrial DNA (mtDNA) sequences (ca. 16,000 bp) of...
2.
Matsuoka K, Wada K, Miyasaka Y, Yasuda S, Seki Y, Nishito Y, et al.
Sci Rep
. 2019 Mar;
9(1):5285.
PMID: 30918314
Outer hair cells (OHCs) are responsible for the amplification of sound, and the death of these cells leads to hearing loss. Although the mechanisms for sound amplification and OHC death...
3.
Tani H, Ohnishi S, Shitara H, Mito T, Yamaguchi M, Yonekawa H, et al.
Sci Rep
. 2018 Jan;
8(1):425.
PMID: 29323231
Accumulation of somatic mutations in mitochondrial DNA (mtDNA) has been proposed to be responsible for human aging and age-associated mitochondrial respiration defects. However, our previous findings suggested an alternative hypothesis...
4.
Ohta T, Yoshikawa S, Tabakawa Y, Yamaji K, Ishiwata K, Shitara H, et al.
Front Immunol
. 2017 Nov;
8:1348.
PMID: 29085376
Ticks, blood-sucking arthropods, serve as vectors for transmission of infectious diseases including Lyme borreliosis. After tick infestation, several animal species can develop resistance to subsequent infestations, reducing the risk of...
5.
Shitara H, Cao L, Yamaguchi M, Yonekawa H, Taya C
Transgenic Res
. 2017 Feb;
26(4):559-565.
PMID: 28220277
Mitochondrial DNA segregation is one of the characteristic modes of mitochondrial inheritance in which the heteroplasmic state of mitochondrial DNA is transmitted to the next generation in variable proportions. To...
6.
Miyasaka Y, Shitara H, Suzuki S, Yoshimoto S, Seki Y, Ohshiba Y, et al.
Hum Mol Genet
. 2016 Mar;
25(10):2045-2059.
PMID: 26936824
Most clinical reports have suggested that patients with congenital profound hearing loss have recessive mutations in deafness genes, whereas dominant alleles are associated with progressive hearing loss (PHL). Jackson shaker...
7.
Nishimura T, Kaminuma O, Saeki M, Kitamura N, Matsuoka K, Yonekawa H, et al.
PLoS One
. 2016 Jan;
11(1):e0146686.
PMID: 26752722
Nasal hyperresponsiveness (NHR) is a characteristic feature of allergic rhinitis (AR); however, the pathogenesis of NHR is not fully understood. In this study, during the establishment of an experimental AR...
8.
Shimizu A, Enoki S, Ishikawa K, Mito T, Obata K, Nagashima R, et al.
Biochem Biophys Res Commun
. 2015 Sep;
467(4):1097-102.
PMID: 26381171
We searched for mtDNA harboring somatic mutations in mouse B82 cells, and found an A2748G mutation orthologous to the A3302G mutation in tRNA(Leu(UUR)) gene reported in a patient with MELAS,...
9.
Shimizu A, Mito T, Hashizume O, Yonekawa H, Ishikawa K, Nakada K, et al.
Biochem Biophys Res Commun
. 2015 Feb;
459(1):66-70.
PMID: 25721669
We previously generated mito-mice-tRNA(Lys7731) as a model for primary prevention of mitochondrial diseases. These mice harbour a G7731A mtDNA mutation in the tRNA(Lys) gene, but express only muscle weakness and...
10.
Yamanashi H, Hashizume O, Yonekawa H, Nakada K, Hayashi J
Exp Anim
. 2014 Jul;
63(4):459-66.
PMID: 25048265
Because of the difficulty to exclude possible involvement of nuclear DNA mutations, it has been a controversial issue whether pathogenic mutations in mitochondrial DNA (mtDNA) and the resultant respiration defects...