Sumiyo Morita
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Explore the profile of Sumiyo Morita including associated specialties, affiliations and a list of published articles.
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46
Citations
1124
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Recent Articles
1.
Kobayashi R, Tajika Y, Kohmaru J, Morita S, Horii T, Mizukami Y, et al.
Cell Death Discov
. 2024 Aug;
10(1):357.
PMID: 39117610
Embryo implantation failures are a major challenge in reproductive medicine, but the underlying mechanism remains poorly understood. Successful implantation requires dynamic remodeling of the endometrium through integrated proliferation and differentiation...
2.
Morita S, Horii T, Hatada I
Methods Mol Biol
. 2024 Jul;
2842:155-165.
PMID: 39012594
DNA methylation, one of the most studied epigenetic modifications, regulates many biological processes. Dysregulation of DNA methylation is implicated in the etiology of several diseases, such as cancer and imprinting...
3.
Morita S, Horii T, Kimura M, Kobayashi R, Tanaka H, Akita H, et al.
Int J Mol Sci
. 2023 Sep;
24(18).
PMID: 37762602
Knockout mice are useful tools that can provide information about the normal function of genes, including their biochemical, developmental, and physiological roles. One problem associated with the generation of knockout...
4.
Kobayashi R, Kawabata-Iwakawa R, Terakawa J, Sugiyama M, Morita S, Horii T, et al.
FASEB J
. 2023 Jul;
37(8):e23093.
PMID: 37440278
The precise control of endometrial receptivity is crucial for successful embryo implantation, which is strictly regulated by the ovarian steroid hormones estrogen and progesterone. Despite our improved understanding of the...
5.
Suzuki T, Komatsu T, Shibata H, Tanioka A, Vargas D, Kawabata-Iwakawa R, et al.
Nucleic Acids Res
. 2023 May;
51(12):6120-6142.
PMID: 37158274
Iron metabolism is closely associated with the pathogenesis of obesity. However, the mechanism of the iron-dependent regulation of adipocyte differentiation remains unclear. Here, we show that iron is essential for...
6.
Hatada I, Morita S, Horii T
Methods Mol Biol
. 2023 Feb;
2637:41-47.
PMID: 36773136
CRISPR/Cas9 is the genome-editing technology that is most widely used around the world. Its widespread adoption is largely due to its simplicity and ease of use. Here, we introduce the...
7.
Horii T, Morita S, Kimura M, Hatada I
Epigenetics Chromatin
. 2022 Dec;
15(1):40.
PMID: 36522780
Background: Epigenome-edited animal models enable direct demonstration of disease causing epigenetic mutations. Transgenic (TG) mice stably expressing epigenome-editing factors exhibit dramatic and stable changes in target epigenome modifications. Successful germline...
8.
Kobayashi R, Kawabata-Iwakawa R, Sugiyama M, Oyama T, Ohtsuka M, Horii T, et al.
Int J Cancer
. 2022 Nov;
152(11):2331-2337.
PMID: 36378073
Synergistic effects among multiple gene mutations are involved in cancer development and progression. However, developing genetically modified mouse models to analyze various combinations of mutations is extremely labor-intensive and time-consuming....
9.
Horii T, Morita S, Hatada I
Methods Mol Biol
. 2022 Sep;
2577:255-268.
PMID: 36173579
Epigenetic regulatory mechanisms play an important role in gene silencing and genome stability; therefore, epigenetic mutations cause a variety of diseases. Analysis of the epigenome by next-generation sequencers has revealed...
10.
Morita S, Horii T, Hatada I
Methods Mol Biol
. 2022 Sep;
2577:189-195.
PMID: 36173574
Regulating gene expression is important for basic research and therapeutic applications. The epigenome is a record of genetic modifications such as DNA methylation and histone modifications, and epigenetic changes can...