Yael Mandel-Gutfreund
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Explore the profile of Yael Mandel-Gutfreund including associated specialties, affiliations and a list of published articles.
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64
Citations
1970
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Recent Articles
1.
Herbst E, Mandel-Gutfreund Y, Yakhini Z, Biran H
Commun Biol
. 2025 Jan;
8(1):87.
PMID: 39827321
The activity of miRNA varies across different cell populations and systems, as part of the mechanisms that distinguish cell types and roles in living organisms and in human health and...
2.
Argoetti A, Shalev D, Polyak G, Shima N, Biran H, Lahav T, et al.
Nat Commun
. 2025 Jan;
16(1):571.
PMID: 39794357
Long non-coding RNAs (lncRNAs) are pivotal regulators of cellular processes. Here we reveal an interaction between the lncRNA NORAD, noted for its role in DNA stability, and the immune related...
3.
Biran H, Hashimshony T, Lahav T, Efrat O, Mandel-Gutfreund Y, Yakhini Z
Sci Rep
. 2024 Oct;
14(1):26121.
PMID: 39478009
Gene expression data holds the potential to shed light on multiple biological processes at once. However, data analysis methods for single cell sequencing mostly focus on finding cell clusters or...
4.
Gilda J, Nahar A, Kasiviswanathan D, Tropp N, Gilinski T, Lahav T, et al.
J Cell Biol
. 2024 May;
223(8).
PMID: 38767572
Proteasome activity is crucial for cellular integrity, but how tissues adjust proteasome content in response to catabolic stimuli is uncertain. Here, we demonstrate that transcriptional coordination by multiple transcription factors...
5.
Alfi O, Cohen M, Bar-On S, Hashimshony T, Levitt L, Raz Y, et al.
Cell Rep
. 2024 Jan;
43(2):113698.
PMID: 38265934
Congenital cytomegalovirus (cCMV) is the most common intrauterine infection, leading to infant neurodevelopmental disabilities. An improved knowledge of correlates of protection against cCMV is needed to guide prevention strategies. Here,...
6.
A dual role of RBM42 in modulating splicing and translation of CDKN1A/p21 during DNA damage response
Ben-Oz B, Machour F, Nicola M, Argoetti A, Polyak G, Hanna R, et al.
Nat Commun
. 2023 Nov;
14(1):7628.
PMID: 37993446
p53-mediated cell cycle arrest during DNA damage is dependent on the induction of p21 protein, encoded by the CDKN1A gene. p21 inhibits cyclin-dependent kinases required for cell cycle progression to...
7.
Kshirsagar A, Doroshev S, Gorelik A, Olender T, Sapir T, Tsuboi D, et al.
Nat Commun
. 2023 Jun;
14(1):3293.
PMID: 37280197
Lissencephaly-1 (LIS1) is associated with neurodevelopmental diseases and is known to regulate the molecular motor cytoplasmic dynein activity. Here we show that LIS1 is essential for the viability of mouse...
8.
Gilda J, Nahar A, Kasiviswanathan D, Tropp N, Gilinski T, Lahav T, et al.
bioRxiv
. 2023 May;
PMID: 37205440
Proteasome activity is crucial for cellular integrity, but how tissues adjust proteasome content in response to catabolic stimuli is uncertain. Here, we demonstrate that transcriptional coordination by multiple transcription factors...
9.
Paz I, Argoetti A, Cohen N, Even N, Mandel-Gutfreund Y
Methods Mol Biol
. 2021 Oct;
2404:53-65.
PMID: 34694603
RNA-binding proteins (RBPs) play a key role in post-transcriptional regulation via binding to coding and non-coding RNAs. Recent development in experimental technologies, aimed to identify the targets of RBPs, has...
10.
Dvir S, Argoetti A, Lesnik C, Roytblat M, Shriki K, Amit M, et al.
Cell Rep
. 2021 Jun;
35(9):109198.
PMID: 34077720
Embryonic stem cell (ESC) self-renewal and cell fate decisions are driven by a broad array of molecular signals. While transcriptional regulators have been extensively studied in human ESCs (hESCs), the...