Martin Akerman
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Explore the profile of Martin Akerman including associated specialties, affiliations and a list of published articles.
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22
Citations
1533
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Recent Articles
1.
Fronk A, Manzanares M, Zheng P, Geier A, Anderson K, Stanton S, et al.
Mol Syst Biol
. 2024 Apr;
20(6):676-701.
PMID: 38664594
Splice-switching oligonucleotides (SSOs) are antisense compounds that act directly on pre-mRNA to modulate alternative splicing (AS). This study demonstrates the value that artificial intelligence/machine learning (AI/ML) provides for the identification...
2.
Sathe A, Zhang Y, Ma X, Ray P, Cadinu D, Wang Y, et al.
IEEE Life Sci Lett
. 2021 Mar;
1(3):30-33.
PMID: 33758771
Aberrant DNA methylation has long been implicated in cancers. In this work we present a highly discriminative DNA methylation biomarker for non-small cell lung cancers and fourteen other cancers. Based...
3.
Park S, Brugiolo M, Akerman M, Das S, Urbanski L, Geier A, et al.
Cell Rep
. 2019 Nov;
29(9):2672-2688.e7.
PMID: 31775037
Misregulation of alternative splicing is a hallmark of human tumors, yet to what extent and how it contributes to malignancy are only beginning to be unraveled. Here, we define which...
4.
Sheng L, Wan B, Feng P, Sun J, Rigo F, Bennett C, et al.
Hum Mol Genet
. 2017 Dec;
27(3):486-498.
PMID: 29220503
Spinal muscular atrophy (SMA) is the leading genetic cause of infant mortality, characterized by progressive degeneration of spinal-cord motor neurons, leading to atrophy of skeletal muscles. However, accumulating evidence indicates...
5.
Arun G, Diermeier S, Akerman M, Chang K, Wilkinson J, Hearn S, et al.
Genes Dev
. 2015 Dec;
30(1):34-51.
PMID: 26701265
Genome-wide analyses have identified thousands of long noncoding RNAs (lncRNAs). Malat1 (metastasis-associated lung adenocarcinoma transcript 1) is among the most abundant lncRNAs whose expression is altered in numerous cancers. Here...
6.
Anczukow O, Akerman M, Clery A, Wu J, Shen C, Shirole N, et al.
Mol Cell
. 2015 Oct;
60(1):105-17.
PMID: 26431027
Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression promotes transformation of mammary cells. Using RNA-seq, we identified SRSF1-regulated alternative splicing (AS) targets in organotypic three-dimensional MCF-10A...
7.
Akerman M, Fregoso O, Das S, Ruse C, Jensen M, Pappin D, et al.
Genome Biol
. 2015 Jun;
16:119.
PMID: 26047612
Background: During spliceosome assembly, protein-protein interactions (PPI) are sequentially formed and disrupted to accommodate the spatial requirements of pre-mRNA substrate recognition and catalysis. Splicing activators and repressors, such as SR...
8.
Fregoso O, Das S, Akerman M, Krainer A
Mol Cell
. 2013 Mar;
50(1):56-66.
PMID: 23478443
Splicing and translation are highly regulated steps of gene expression. Altered expression of proteins involved in these processes can be deleterious. Therefore, the cell has many safeguards against such misregulation....
9.
Roca X, Akerman M, Gaus H, Berdeja A, Bennett C, Krainer A
Genes Dev
. 2012 May;
26(10):1098-109.
PMID: 22588721
An established paradigm in pre-mRNA splicing is the recognition of the 5' splice site (5'ss) by canonical base-pairing to the 5' end of U1 small nuclear RNA (snRNA). We recently...
10.
Das S, Anczukow O, Akerman M, Krainer A
Cell Rep
. 2012 May;
1(2):110-7.
PMID: 22545246
The SR protein splicing factor SRSF1 is a potent proto-oncogene that is frequently upregulated in cancer. Here, we show that SRSF1 is a direct target of the transcription factor oncoprotein...