Y C Awasthi
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Explore the profile of Y C Awasthi including associated specialties, affiliations and a list of published articles.
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188
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2038
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Recent Articles
1.
Xu Y, Gong B, Yang Y, Awasthi Y, Woods M, Boor P
Endothelium
. 2007 Dec;
14(6):333-43.
PMID: 18080870
Oxidative damage of endothelial tight junction permeability is involved in the pathophysiology of a variety of vascular diseases. The authors studied the role of the antioxidant enzyme, human glutathione-S-transferase A4-4...
2.
SINGHAL S, Singhal J, Cheng J, Pikula S, Sharma R, Zimniak P, et al.
Acta Biochim Pol
. 2001 Dec;
48(2):551-62.
PMID: 11732624
We have recently shown that RLIP76, a ral-binding GTPase activating protein, mediates ATP-dependent transport of glutathione-conjugates (GS-E) and doxorubicin (DOX) (S. Awasthi et al., Biochemistry 39,9327,2000). Transport function of RLIP76...
3.
Cheng J, Sharma R, Yang Y, SINGHAL S, Sharma A, Saini M, et al.
J Biol Chem
. 2001 Aug;
276(44):41213-23.
PMID: 11522795
To explore the role of lipid peroxidation (LPO) products in the initial phase of stress mediated signaling, we studied the effect of mild, transient oxidative or heat stress on parameters...
4.
Cheng J, SINGHAL S, Sharma A, Saini M, Yang Y, Awasthi S, et al.
Arch Biochem Biophys
. 2001 Aug;
392(2):197-207.
PMID: 11488593
The mammalian alpha-class glutathione S-transferase (GST) isozymes mGSTA4-4, rGSTA4-4, and hGSTA4-4 are known to utilize 4-hydroxynonenal (4HNE) as a preferred substrate. During the present studies, we have examined the effect...
5.
Sharma R, SINGHAL S, Cheng J, Yang Y, Sharma A, Zimniak P, et al.
Arch Biochem Biophys
. 2001 Jul;
391(2):171-9.
PMID: 11437348
We have recently demonstrated that RLIP76, a Ral-binding GTPase activating protein mediates ATP-dependent transport of glutathione (GSH) conjugates of electrophiles (GS-E) as well as doxorubicin (DOX), and that it is...
6.
Sharma R, Awasthi S, Zimniak P, Awasthi Y
Acta Biochim Pol
. 2001 Apr;
47(3):751-62.
PMID: 11310974
The last step of detoxification of both endogenous and environmental toxicants is typically a conjugation that produces a bulky hydrophilic molecule. The excretion of such conjugates out of cells is...
7.
Cheng J, Yang Y, Singh S, SINGHAL S, Awasthi S, Pan S, et al.
Biochem Biophys Res Commun
. 2001 Apr;
282(5):1268-74.
PMID: 11302754
The two previously reported human glutathione S-transferase isozymes, hGST5.8 and hGSTA4-4, have been suggested to be similar because of their comparable activities toward 4-hydroxynonenal-GSH conjugation. Here, we demonstrate that hGST5.8...
8.
Awasthi S, Cheng J, SINGHAL S, Pandya U, Sharma R, Singh S, et al.
Biochemistry
. 2001 Apr;
40(13):4159-68.
PMID: 11300797
We have recently shown that RLIP76, a Ral-binding, GTPase-activating protein, is an ATP-dependent transporter of doxorubicin (DOX) as well as glutathione conjugates [Awasthi, S., et al. (2000) Biochemistry 39, 9327-9334]....
9.
Yang Y, Cheng J, SINGHAL S, Saini M, Pandya U, Awasthi S, et al.
J Biol Chem
. 2001 Mar;
276(22):19220-30.
PMID: 11279091
The physiological significance of the selenium-independent glutathione peroxidase (GPx) activity of glutathione S-transferases (GSTs), associated with the major Alpha class isoenzymes hGSTA1-1 and hGSTA2-2, is not known. In the present...
10.
Pandya U, Srivastava S, SINGHAL S, Pal A, Awasthi S, Zimniak P, et al.
Biochem Biophys Res Commun
. 2000 Nov;
278(1):258-62.
PMID: 11071881
Clinical efficacy of alkylating anticancer drugs, such as chlorambucil, is often limited by the emergence of drug resistant tumor cells. Increased glutathione (GSH) conjugation (inactivation) of alkylating anticancer drugs or...