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Y C Awasthi

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Articles 188
Citations 2038
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Recent Articles
11.
Awasthi S, Pandya U, SINGHAL S, Lin J, Thiviyanathan V, Seifert Jr W, et al.
Chem Biol Interact . 2000 Sep; 128(1):19-38. PMID: 10996298
Curcumin (diferuloylmethane), a yellow pigment of turmeric with antioxidant properties has been shown to be a cancer preventative in animal studies. It contains two electrophilic alpha, beta-unsaturated carbonyl groups, which...
12.
Awasthi S, Cheng J, SINGHAL S, Saini M, Pandya U, Pikula S, et al.
Biochemistry . 2000 Aug; 39(31):9327-34. PMID: 10924126
Active transport of conjugated and unconjugated electrophiles out of cells is essential for cellular homeostasis. We have previously identified in human tissues a transporter, DNP-SG [S-(2, 4-dinitrophenyl)glutathione] ATPase, capable of...
13.
Pandya U, Saini M, Jin G, Awasthi S, Godley B, Awasthi Y
Toxicol Lett . 2000 May; 115(3):195-204. PMID: 10814889
Administration of naphthalene is known to cause cataract formation in rats and rabbits and naphthalene-initiated cataract is frequently used as a model for studies on senile cataract in humans. Oxidative...
14.
Cheng J, SINGHAL S, Saini M, Singhal J, Piper J, Van Kuijk F, et al.
Arch Biochem Biophys . 1999 Nov; 372(1):29-36. PMID: 10562413
Cellular levels of downstream products of membrane lipid oxidation appear to regulate differentiation in K562 human erythroleukemia cells. 4-Hydroxynonenal (4-HNE) is a diffusible and relatively stable product of peroxidation of...
15.
SINGHAL S, Awasthi S, Pandya U, Piper J, Saini M, Cheng J, et al.
Toxicol Lett . 1999 Oct; 109(1-2):87-95. PMID: 10514034
Curcumin, an antioxidant present in the spice turmeric (Curcuma longa), has been shown to inhibit chemical carcinogenesis in animal models and has been shown to be an anti-inflammatory agent. While...
16.
SINGHAL S, Godley B, Chandra A, Pandya U, Jin G, Saini M, et al.
Invest Ophthalmol Vis Sci . 1999 Oct; 40(11):2652-9. PMID: 10509662
Purpose: To delineate the role of the glutathione S-transferase (GST) isozyme hGST 5.8 in protection mechanisms against oxidative stress, the effect of low-level transient exposure of H2O2 to retinal pigmented...
17.
Xiao B, Singh S, Nanduri B, Awasthi Y, Zimniak P, Ji X
Biochemistry . 1999 Oct; 38(37):11887-94. PMID: 10508391
mGSTA4-4, a murine glutathione S-transferase (GST) exhibiting high activity in conjugating the lipid peroxidation product 4-hydroxynon-2-enal (4-HNE) with glutathione (GSH), was crystallized in complex with the GSH conjugate of 4-HNE...
18.
Horton J, Roy G, Piper J, Van Houten B, Awasthi Y, Mitra S, et al.
Biochem Pharmacol . 1999 Jul; 58(4):693-702. PMID: 10413308
Ovarian carcinoma cells 10-fold resistant to the alkylating agent chlorambucil (CBL) were isolated after repeated exposure of the parent cells to gradually escalating concentrations of the drug. The resistant variant,...
19.
Zimniak P, Pikula S, Bandorowicz-Pikula J, Awasthi Y
Toxicol Lett . 1999 Jul; 106(2-3):107-18. PMID: 10403654
No abstract available.
20.
Zhao T, SINGHAL S, Piper J, Cheng J, Pandya U, Awasthi S, et al.
Arch Biochem Biophys . 1999 Jul; 367(2):216-24. PMID: 10395737
In order to elucidate the protective role of glutathione S-transferases (GSTs) against oxidative stress, we have investigated the kinetic properties of the human alpha-class GSTs, hGSTA1-1 and hGSTA2-2, toward physiologically...