J T Piper
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Explore the profile of J T Piper including associated specialties, affiliations and a list of published articles.
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14
Citations
210
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Recent Articles
1.
Cheng J, SINGHAL S, Saini M, Singhal J, Piper J, Van Kuijk F, et al.
Arch Biochem Biophys
. 1999 Nov;
372(1):29-36.
PMID: 10562413
Cellular levels of downstream products of membrane lipid oxidation appear to regulate differentiation in K562 human erythroleukemia cells. 4-Hydroxynonenal (4-HNE) is a diffusible and relatively stable product of peroxidation of...
2.
SINGHAL S, Awasthi S, Pandya U, Piper J, Saini M, Cheng J, et al.
Toxicol Lett
. 1999 Oct;
109(1-2):87-95.
PMID: 10514034
Curcumin, an antioxidant present in the spice turmeric (Curcuma longa), has been shown to inhibit chemical carcinogenesis in animal models and has been shown to be an anti-inflammatory agent. While...
3.
Horton J, Roy G, Piper J, Van Houten B, Awasthi Y, Mitra S, et al.
Biochem Pharmacol
. 1999 Jul;
58(4):693-702.
PMID: 10413308
Ovarian carcinoma cells 10-fold resistant to the alkylating agent chlorambucil (CBL) were isolated after repeated exposure of the parent cells to gradually escalating concentrations of the drug. The resistant variant,...
4.
Zhao T, SINGHAL S, Piper J, Cheng J, Pandya U, Awasthi S, et al.
Arch Biochem Biophys
. 1999 Jul;
367(2):216-24.
PMID: 10395737
In order to elucidate the protective role of glutathione S-transferases (GSTs) against oxidative stress, we have investigated the kinetic properties of the human alpha-class GSTs, hGSTA1-1 and hGSTA2-2, toward physiologically...
5.
Piper J, SINGHAL S, Salameh M, Torman R, Awasthi Y, Awasthi S
Int J Biochem Cell Biol
. 1998 Jul;
30(4):445-56.
PMID: 9675878
Curcumin, an antioxidant isolated from turmeric (curcuma longa), has been shown to attenuate chemical carcinogenesis in rodents. Previous studies have shown that curcumin causes an increase in glutathione S-transferase (GST)...
6.
Awasthi S, SINGHAL S, Pikula S, Piper J, Srivastava S, Torman R, et al.
Biochemistry
. 1998 May;
37(15):5239-48.
PMID: 9548755
Purified dinitrophenyl S-glutathione (DNP-SG) ATPase was reconstituted into artificial liposomes prepared from soybean asolectin. Electron micrography confirmed the formation of unilamellar vesicles with an average radius of 0.25 micron. Intravesicular...
7.
Awasthi S, SINGHAL S, Srivastava S, Torman R, Zimniak P, Bandorowicz-Pikula J, et al.
Biochemistry
. 1998 May;
37(15):5231-8.
PMID: 9548754
Dinitrophenyl S-glutathione (DNP-SG) ATPase is a 38 kDa membrane protein expressed in erythrocytes and other tissues. Although stimulation of ATP hydrolysis catalyzed by DNP-SG ATPase has been demonstrated in the...
8.
Sharma R, Haque A, Awasthi S, Singh S, Piper J, Awasthi Y
J Toxicol Environ Health
. 1997 Sep;
52(1):45-62.
PMID: 9269322
Benzo[a]pyrene (BaP) is known to induce tumors in lung, forestomach, and skin in experimental animals. Earlier studies have suggested that glutathione S-transferase pi (GST pi) is involved in the detoxification...
9.
Awasthi S, SINGHAL S, Srivastava S, Chaubey M, Piper J, Zimniak P, et al.
Int J Biochem Cell Biol
. 1997 May;
29(5):807-13.
PMID: 9251248
Previous studies from our laboratory have shown a relatively high expression of rGST8-8 in uterine tissues. This GST isozyme displays relatively high glutathione-peroxidase activity towards lipid-hydroperoxides and towards toxic 4-hydroxyalkenals...
10.
SINGHAL S, Yallampalli C, Singhal J, Piper J, Awasthi S
Int J Biochem Cell Biol
. 1996 Nov;
28(11):1271-83.
PMID: 9022286
Glutathione S-transferases (GSTs) provide protection to cells against electrophilic xenobiotics as well as lipid hydroperoxides and 4-hydroxynonenal generated during lipid peroxidation. The catalytic properties of the alpha class GSTs are...