Xuxu Yan
Overview
Explore the profile of Xuxu Yan including associated specialties, affiliations and a list of published articles.
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11
Citations
119
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Recent Articles
1.
Duan Y, Yan X, Wei L, Bensimon C, Fernando P, Ruddy T
Regul Toxicol Pharmacol
. 2016 May;
80:195-209.
PMID: 27177822
Purpose: Extensive acute and subacute toxicities studies are required to evaluate the toxicological profile of the novel cardiac perfusion imaging tracer (123)I-CMICE-013 to support applications for clinical trials. Methods: Sprague-Dawley...
2.
Wei L, Bensimon C, Yan X, Lockwood J, Gan W, Wells R, et al.
Bioorg Med Chem
. 2014 Mar;
22(7):2033-44.
PMID: 24630696
Unlabelled: Myocardial perfusion imaging (MPI) with single photon emission computed tomography (SPECT) is widely used in the assessment of coronary artery disease (CAD). We have developed (123)I-CMICE-013 based on rotenone,...
3.
Fernando P, Yan X, Lockwood J, Duan Y, Wei L, Wells R, et al.
Cardiovasc Toxicol
. 2014 Jan;
14(2):170-82.
PMID: 24395712
Myocardial perfusion scintigraphy is a valuable clinical tool for assessing coronary blood flow deficits in patients. We recently synthesized a new iodinated compound ((123)I-CMICE-013) based on rotenone and showed that...
4.
Wei L, Bensimon C, Lockwood J, Yan X, Fernando P, Wells R, et al.
Bioorg Med Chem
. 2013 Apr;
21(11):2903-11.
PMID: 23608108
Unlabelled: Coronary artery disease (CAD) is a major cause of death in Canada and the United States. Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is a useful...
5.
Vong K, Tam I, Yan X, Auclair K
ACS Chem Biol
. 2012 Jan;
7(3):470-5.
PMID: 22217014
The most common mechanism of resistance to aminoglycoside antibiotics entails bacterial expression of drug-metabolizing enzymes, such as the clinically widespread aminoglycoside N-6'-acetyltransferase (AAC(6')). Aminoglycoside-CoA bisubstrates are highly potent AAC(6') inhibitors;...
6.
Yan X, Akinnusi T, Larsen A, Auclair K
Org Biomol Chem
. 2011 Jan;
9(5):1538-46.
PMID: 21225062
A convenient synthesis of 4'-aminopantetheine from commercial D-pantethine is reported. The amino group was introduced by reductive amination in order to avoid substitution at a sterically congested position. Derivatives of...
7.
Gao F, Yan X, Auclair K
Chemistry
. 2009 Jan;
15(9):2064-70.
PMID: 19152351
Just five steps! The synthesis of a phosphonate-linked aminoglycoside-coenzyme A derivative (see scheme) that includes a Michael addition in water has been realized in just five steps. Aminoglycoside N-6'-acetyltransferases (AAC(6')s)...
8.
Gao F, Yan X, Zahr O, Larsen A, Vong K, Auclair K
Bioorg Med Chem Lett
. 2008 Sep;
18(20):5518-22.
PMID: 18805003
Aminoglycoside-coenzyme A conjugates are challenging synthetic targets because of the wealth of functional groups and high polarity of the starting materials. We previously reported a one-pot synthesis of amide-linked aminoglycoside-CoA...
9.
Yan X, Gao F, Yotphan S, Bakirtzian P, Auclair K
Bioorg Med Chem
. 2007 Feb;
15(8):2944-51.
PMID: 17317190
Aminoglycoside antibiotics act by binding to 16S rRNA. Resistance to these antibiotics occurs via drug modifications by enzymes such as aminoglycoside 6'-N-acetyltransferases (AAC(6')s). We report here the regioselective and efficient...
10.
Gao F, Yan X, Shakya T, Baettig O, Ait-Mohand-Brunet S, Berghuis A, et al.
J Med Chem
. 2006 Aug;
49(17):5273-81.
PMID: 16913716
Truncated aminoglycoside-coenzyme A bisubstrate analogues were efficiently prepared using a convergent approach where the amine and the thiol are coupled in one pot with the addition of a linker, without...