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Xiaowen Peng

Explore the profile of Xiaowen Peng including associated specialties, affiliations and a list of published articles. Areas
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Articles 14
Citations 87
Followers 0
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Recent Articles
1.
Peng X, Holler C, Alves A, Oliviera M, Speake M, Pugliese A, et al.
Bioorg Med Chem Lett . 2023 Dec; 98:129595. PMID: 38141860
Screening a library of >100,000 compounds identified the substituted tetrazole compound 1 as a selective TRPML1 agonist. Both enantiomers of compound 1 were separated and profiled in vitro and in...
2.
Fei J, Chen S, Song X, Liang Y, Duan K, Peng X, et al.
FASEB J . 2023 Nov; 38(1):e23340. PMID: 38031959
Facial nerve regeneration still lacks a well-defined and practical clinical intervention. The survival of central facial motoneuron is a critical component in the successful peripheral facial nerve regeneration. Endogenous GDNF...
3.
Peng X, Lanter J, Chen A, Brand M, Wozniak M, Hoekman S, et al.
Bioorg Med Chem Lett . 2022 Nov; 80:129048. PMID: 36368496
Phenotypic screening of an annotated small molecule library and initial SAR studies identified compound 2 as a robust enhancer of progranulin secretion. Detailed SAR development on conformationally restricted carbamate isosteres...
4.
Zhou J, Peng X, Li X, Kong X
Dis Markers . 2022 Mar; 2021:2174290. PMID: 35356669
In the current study, a Cu(II) coordination polymer (CP) has been created in success with the solvothermal reaction between an asymmetrical rigid N-heterocyclic carboxylatic acid (HL) and Cu(NO)·3HO in the...
5.
Huang Y, Luo Y, Ou W, Wang Y, Dong D, Peng X, et al.
Cancer Cell Int . 2022 Feb; 22(1):55. PMID: 35109830
No abstract available.
6.
Huang Y, Luo Y, Ou W, Wang Y, Dong D, Peng X, et al.
Cancer Cell Int . 2021 Oct; 21(1):528. PMID: 34641864
Background: Exosome-mediated crosstalk between cancer cells and immune cells contributes to tumor growth. In this study, we investigated the mechanism underlying the exosome-mediated immune escape of colorectal cancer (CRC) cells...
7.
Luo Y, Sun F, Peng X, Dong D, Ou W, Xie Y, et al.
Int J Gen Med . 2021 Sep; 14:4745-4756. PMID: 34466019
Objective: To identify the value of key differentially expressed genes (DEGs) regulated by differentially methylated regions (DMRs) in predicting the prognosis of human colon cancer. Materials And Methods: RNA sequencing...
8.
Owens C, Brasher B, Polemeropoulos A, Rhodin M, McAllister N, Peng X, et al.
Antimicrob Agents Chemother . 2016 Aug; 60(10):6207-15. PMID: 27503640
EDP-239, a novel hepatitis C virus (HCV) inhibitor targeting nonstructural protein 5A (NS5A), has been investigated in vitro and in vivo EDP-239 is a potent, selective inhibitor with potency at...
9.
Hoveyda H, Marsault E, Gagnon R, Mathieu A, Vezina M, Landry A, et al.
J Med Chem . 2011 Nov; 54(24):8305-20. PMID: 22106937
High-throughput screening of Tranzyme Pharma's proprietary macrocycle library using the aequorin Ca2+-bioluminescence assay against the human ghrelin receptor (GRLN) led to the discovery of novel agonists against this G-protein coupled...
10.
Marsault E, Hoveyda H, Gagnon R, Peterson M, Vezina M, Saint-Louis C, et al.
Bioorg Med Chem Lett . 2008 Jul; 18(16):4731-5. PMID: 18640834
A new method for solid phase parallel synthesis of chemically and conformationally diverse macrocyclic peptidomimetics is reported. A key feature of the method is access to broad chemical and conformational...