Xianrong Wong
Overview
Explore the profile of Xianrong Wong including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
458
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0
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Recent Articles
1.
Reddy K, Wong X
Methods Mol Biol
. 2024 Nov;
2866:245-262.
PMID: 39546207
Recent studies have implicated higher-order genome organization in the regulation of genes and cellular state. Lamina-Associated Domains (LADs) are regions of heterochromatin associated with the nuclear envelope and the nuclear...
2.
Vahabikashi A, Sivagurunathan S, Nicdao F, Han Y, Park C, Kittisopikul M, et al.
Proc Natl Acad Sci U S A
. 2022 Apr;
119(17):e2121816119.
PMID: 35439057
The ability of a cell to regulate its mechanical properties is central to its function. Emerging evidence suggests that interactions between the cell nucleus and cytoskeleton influence cell mechanics through...
3.
Wong X, Hoskins V, Melendez-Perez A, Harr J, Gordon M, Reddy K
Genome Biol
. 2021 Nov;
22(1):305.
PMID: 34775987
Background: The dynamic 3D organization of the genome is central to gene regulation and development. The nuclear lamina influences genome organization through the tethering of lamina-associated domains (LADs) to the...
4.
Wong X, Melendez-Perez A, Reddy K
Cold Spring Harb Perspect Biol
. 2021 Aug;
14(2).
PMID: 34400553
Lamins interact with a host of nuclear membrane proteins, transcription factors, chromatin regulators, signaling molecules, splicing factors, and even chromatin itself to form a nuclear subcompartment, the nuclear lamina, that...
5.
Wong X, Cutler J, Hoskins V, Gordon M, Madugundu A, Pandey A, et al.
Life Sci Alliance
. 2021 Mar;
4(5).
PMID: 33758005
The nuclear lamina is a proteinaceous network of filaments that provide both structural and gene regulatory functions by tethering proteins and large domains of DNA, the so-called lamina-associated domains (LADs),...
6.
Wong X, Loo T, Stewart C
Curr Opin Genet Dev
. 2021 Feb;
67:130-141.
PMID: 33524904
The regulation of genomic function is in part mediated through the physical organization and architecture of the nucleus. Disruption to nuclear organization and architecture is increasingly being recognized by its...
7.
Wong X, Stewart C
Annu Rev Genomics Hum Genet
. 2020 May;
21:263-288.
PMID: 32428417
In recent years, our perspective on the cell nucleus has evolved from the view that it is a passive but permeable storage organelle housing the cell's genetic material to an...
8.
Chojnowski A, Sobota R, Ong P, Xie W, Wong X, Dreesen O, et al.
iScience
. 2018 Dec;
10:40-52.
PMID: 30500481
The modulation of protein-protein interactions (PPIs) is an essential regulatory activity defining diverse cell functions in development and disease. BioID is an unbiased proximity-dependent biotinylation method making use of a...
9.
Chen S, Luperchio T, Wong X, Doan E, Byrd A, Roy Choudhury K, et al.
Cell Rep
. 2018 Nov;
25(7):1729-1740.e6.
PMID: 30428344
Tcrb locus V(D)J recombination is regulated by positioning at the nuclear periphery. Here, we used DamID to profile Tcrb locus interactions with the nuclear lamina at high resolution. We identified...
10.
Wong X, Reddy K
Dev Cell
. 2015 Dec;
35(6):670-1.
PMID: 26702826
Chromatin domains associated with the nuclear lamina are generally heterochromatic and transcriptionally repressed. How they are recruited to and maintained at the nuclear periphery remains unclear. A recent study by...