Xiang-Long Chen
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Explore the profile of Xiang-Long Chen including associated specialties, affiliations and a list of published articles.
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41
Citations
92
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Recent Articles
1.
Zhang H, Qi H, Li Y, Shi X, Hu M, Chen X, et al.
J Comput Aided Mol Des
. 2024 Nov;
38(1):37.
PMID: 39528618
PIK3CA gene encoding PI3K p110α is one of the most frequently mutated and overexpressed in majority of human cancers. Development of potent and selective novel inhibitors targeting PI3Kα was considered...
2.
Yang D, Chen X, Wu C, Zhou Y, Wang L, Wu Y, et al.
J Org Chem
. 2024 Oct;
89(22):16553-16563.
PMID: 39465977
Defluorinative cyclization of CF-alkenes has emerged as a reliable strategy for crafting intricate polycyclic frameworks. In this study, a facile defluorinative bicyclization approach was developed for the construction of 4,5-pyrano[3,2-]chromenes...
3.
Duan L, Li J, Shen L, Chen X, Yu Y, Yang Z, et al.
Antimicrob Agents Chemother
. 2024 Oct;
68(11):e0114824.
PMID: 39382275
This study aimed to develop a pharmacokinetic model of linezolid in premature neonates and evaluate and optimize the administration regimen. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to detect the...
4.
Wu C, Chen X, Yang D, Tang Y, Wang L, Du Y, et al.
Org Lett
. 2024 Sep;
26(40):8589-8593.
PMID: 39329447
A three-component annulation reaction and trifluoromethylation for the construction of 3-(trifluoromethyl)-4-pyrans using β-CF-1,3-enynes, BrCFCOEt, and sulfoxonium ylides as readily available substrates has been developed. This metal-free process involves two C-F...
5.
Yu Z, Zheng K, Shen X, Zhou Y, Chen X, Wang L, et al.
Org Lett
. 2024 Sep;
26(37):7891-7896.
PMID: 39240619
In this paper, novel sulfur-containing 1,6-dihydrofuro[3,2-]pyrazolo[3,4-][1,4]thiazine skeletons were constructed from the simple and readily available materials enaminone, 5-aminopyrazole, and 1,4-dithiane-2,5-diol. Furthermore, a novel 1,4-dithiane-2,5-diol reaction mode has been developed through...
6.
Yang D, Chen X, Wu C, Tang B, Xiao Y, Wu Y, et al.
Org Lett
. 2024 May;
26(20):4340-4345.
PMID: 38743916
An unconventional [1 + 1 + 1 + 1 + 1 + 1] annulation process was developed for the construction of β,β-dithioketones by merging C-C and C-S bond cleavage. In...
7.
Guo Y, Du T, Yang Y, Zhao Y, Chen X, Ma H, et al.
Ther Drug Monit
. 2024 Mar;
46(5):634-641.
PMID: 38531816
Background: Ibrutinib and zanubrutinib are Bruton tyrosine kinase inhibitors used to treat mantle cell lymphoma, chronic lymphocytic leukemia, and small lymphocytic lymphoma. Dihydroxydiol ibrutinib (DHI) is an active metabolite of...
8.
Zhang W, Hu M, Shi X, Chen X, Su X, Qi H, et al.
Mol Divers
. 2024 Jan;
28(6):3949-3963.
PMID: 38240951
Akt1, as an important member of the Akt family, plays a controlled role in cancer cell growth and survival. Inhibition of Akt1 activity can promote cancer cell apoptosis and inhibit...
9.
Wang H, Chen X, Wu C, Yang D, Chen T, Wu A
Org Lett
. 2023 Sep;
25(39):7220-7224.
PMID: 37767992
Herein, we disclose a straightforward approach to access transition-metal-free reductive -formylation of nitroarenes. This reaction integrates the dual role of rongalite, which acts as a reductant and a C1 building...
10.
Yang Y, Qian Z, Zhao Y, Chen X, Huang Q, Guo Y, et al.
Biomed Chromatogr
. 2023 Sep;
37(12):e5738.
PMID: 37724003
We developed and validated sensitive MS/MS methods for the determination of venetoclax, an oral selective B-cell lymphoma-2 inhibitor, in human plasma and cerebrospinal fluid (CSF). Acetonitrile was used as protein...