Xavier Michelet
Overview
Explore the profile of Xavier Michelet including associated specialties, affiliations and a list of published articles.
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20
Citations
963
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Recent Articles
1.
Hammond T, Purbhoo M, Kadel S, Ritz J, Nikiforow S, Daley H, et al.
Nat Commun
. 2024 Feb;
15(1):974.
PMID: 38321023
Invariant natural killer T (iNKT) cells, a unique T cell population, lend themselves for use as adoptive therapy due to diverse roles in orchestrating immune responses. Originally developed for use...
2.
Patskovsky Y, Natarajan A, Patskovska L, Nyovanie S, Joshi B, Morin B, et al.
Nat Commun
. 2023 Jul;
14(1):4522.
PMID: 37500629
No abstract available.
3.
Duquette D, Harmon C, Zaborowski A, Michelet X, OFarrelly C, Winter D, et al.
J Immunol
. 2023 Jul;
211(4):633-647.
PMID: 37449888
NK cells and CD8 T cells use cytotoxic molecules to kill virally infected and tumor cell targets. While perforin and granzyme B (GzmB) are the most commonly studied lytic molecules,...
4.
Patskovsky Y, Natarajan A, Patskovska L, Nyovanie S, Joshi B, Morin B, et al.
Nat Commun
. 2023 Jun;
14(1):3763.
PMID: 37353482
Altered protein phosphorylation in cancer cells often leads to surface presentation of phosphopeptide neoantigens. However, their role in cancer immunogenicity remains unclear. Here we describe a mechanism by which an...
5.
Yang J, Hsu J, Park S, Lee S, Li J, Bai M, et al.
Nat Commun
. 2019 Sep;
10(1):4068.
PMID: 31492851
The aldehyde dehydrogenase (ALDH) family of metabolic enzymes converts aldehydes to carboxylates. Here, we find that the reductive consequence of ALDH7A1 activity, which generates NADH (nicotinamide adenine dinucleotide, reduced form)...
6.
Michelet X, Dyck L, Hogan A, Loftus R, Duquette D, Wei K, et al.
Nat Immunol
. 2018 Nov;
19(12):1330-1340.
PMID: 30420624
Up to 49% of certain types of cancer are attributed to obesity, and potential mechanisms include overproduction of hormones, adipokines, and insulin. Cytotoxic immune cells, including natural killer (NK) cells...
7.
Michelet X, Tuli A, Gan H, Geadas C, Sharma M, Remold H, et al.
J Immunol
. 2018 Mar;
200(9):3160-3169.
PMID: 29592961
is an extremely successful pathogen, and its success is widely attributed to its ability to manipulate the intracellular environment of macrophages. A central phenomenon of tuberculosis pathology enabling immune evasion...
8.
Chang S, Kohlgruber A, Mizoguchi F, Michelet X, Wolf B, Wei K, et al.
J Clin Invest
. 2017 Aug;
127(9):3300-3312.
PMID: 28758901
M2 macrophages, innate lymphoid type 2 cells (ILC2s), eosinophils, Tregs, and invariant NK T cells (iNKT cells) all help to control adipose tissue inflammation, while M1 macrophages, TNF, and other...
9.
Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity
Boulenouar S, Michelet X, Duquette D, Alvarez D, Hogan A, Dold C, et al.
Immunity
. 2017 Feb;
46(2):273-286.
PMID: 28228283
Adipose tissue has a dynamic immune system that adapts to changes in diet and maintains homeostatic tissue remodeling. Adipose type 1 innate lymphoid cells (AT1-ILCs) promote pro-inflammatory macrophages in obesity,...
10.
Encarnacao M, Espada L, Escrevente C, Mateus D, Ramalho J, Michelet X, et al.
J Cell Biol
. 2016 Jun;
213(6):631-40.
PMID: 27325790
Lysosome exocytosis plays a major role in resealing plasma membrane (PM) disruptions. This process involves two sequential steps. First, lysosomes are recruited to the periphery of the cell and then...