Michael B Brenner
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Explore the profile of Michael B Brenner including associated specialties, affiliations and a list of published articles.
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177
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11984
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Recent Articles
1.
Donado C, Theisen E, Zhang F, Nathan A, Fairfield M, Rupani K, et al.
Nature
. 2025 Feb;
PMID: 39914456
Granzymes are a family of serine proteases mainly expressed by CD8 T cells, natural killer cells, and innate-like lymphocytes. Although their primary function is thought to be the induction of...
2.
Mueller A, Zou A, Marsh L, Kemble S, Nayar S, Watts G, et al.
bioRxiv
. 2025 Jan;
PMID: 39829745
The concept that fibroblasts are critical mediators of inflammation is an emerging paradigm. In rheumatoid arthritis (RA), they are the main producers of IL-6 as well as a host of...
3.
Nguyen H, Jeong Y, Kim Y, Kamiya M, Kim Y, Athar H, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(50):e2401899121.
PMID: 39636853
Fibrosis drives end-organ damage in many diseases. However, clinical trials targeting individual upstream activators of fibroblasts, such as TGFβ, have largely failed. Here, we target the leukemia inhibitory factor receptor...
4.
Tamura T, Cheng C, Villasenor-Altamirano A, Yamada K, Ikeda K, Hayashida K, et al.
Sci Transl Med
. 2024 Dec;
16(776):eadq5796.
PMID: 39630883
Neurological injury drives most deaths and morbidity among patients hospitalized for out-of-hospital cardiac arrest (OHCA). Despite its clinical importance, there are no effective pharmacological therapies targeting post-cardiac arrest (CA) neurological...
5.
Faust H, Cheng T, Korsunsky I, Watts G, Gal-Oz S, Trim W, et al.
Nat Commun
. 2024 Nov;
15(1):9859.
PMID: 39543086
Fibroblasts play critical roles in tissue homeostasis, but in pathologic states they can drive fibrosis, inflammation, and tissue destruction. Little is known about what regulates the homeostatic functions of fibroblasts....
6.
Law C, Wacleche V, Cao Y, Pillai A, Sowerby J, Hancock B, et al.
Nature
. 2024 Jul;
632(8025):E6.
PMID: 39060417
No abstract available.
7.
Law C, Wacleche V, Cao Y, Pillai A, Sowerby J, Hancock B, et al.
Nature
. 2024 Jul;
631(8022):857-866.
PMID: 38987586
Systemic lupus erythematosus (SLE) is prototypical autoimmune disease driven by pathological T cell-B cell interactions. Expansion of T follicular helper (T) and T peripheral helper (T) cells, two T cell...
8.
Dunlap G, Wagner A, Meednu N, Wang R, Zhang F, Ekabe J, et al.
Nat Commun
. 2024 Jun;
15(1):4991.
PMID: 38862501
Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12...
9.
Nguyen H, Jeong Y, Kim Y, Kim Y, Athar H, Castaldi P, et al.
bioRxiv
. 2024 Jun;
PMID: 38826450
Significance Statement: Fibroblasts have a central role in the pathogenesis of fibrotic diseases. However, due to in part to multiple profibrotic stimuli, targeting a single activator of fibroblasts, like TGFβ,...
10.
Donado C, Jonsson A, Theisen E, Zhang F, Nathan A, Rupani K, et al.
bioRxiv
. 2024 Jun;
PMID: 38826230
Granzymes are a family of serine proteases mainly expressed by CD8 T cells, natural killer cells, and innate-like lymphocytes. Although their major role is thought to be the induction of...