X Steven Chen
Overview
Explore the profile of X Steven Chen including associated specialties, affiliations and a list of published articles.
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23
Citations
185
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Recent Articles
1.
Zhang W, Wu C, Huang H, Bleu P, Zambare W, Alvarez J, et al.
Transl Oncol
. 2025 Jan;
52():102238.
PMID: 39754813
Background: Colorectal cancer (CRC) presents significant challenges in chemotherapy response prediction due to its molecular heterogeneity. Current methods often fail to account for the complexity and variability inherent in individual...
2.
Altman J, Olex A, Zboril E, Walker C, Boyd D, Myrick R, et al.
Clin Transl Med
. 2024 Oct;
14(10):e70044.
PMID: 39417215
Background: Breast cancer's complex transcriptional landscape requires an improved understanding of cellular diversity to identify effective treatments. The study of genetic variations among breast cancer subtypes at single-cell resolution has...
3.
Xu C, Xia P, Li J, Lewis K, Ciombor K, Wang L, et al.
Cell Rep Med
. 2024 Jul;
5(8):101661.
PMID: 39059386
Identifying patients with stage II and III colon cancer who will benefit from 5-fluorouracil (5-FU)-based adjuvant chemotherapy is crucial for the advancement of personalized cancer therapy. We employ a semi-supervised...
4.
Lukacsovich D, OShea D, Huang H, Zhang W, Young J, Chen X, et al.
Database (Oxford)
. 2024 Jul;
2024.
PMID: 39028752
Alzheimer's disease (AD) is a common neurodegenerative disorder with a significant impact on aging populations. DNA methylation (DNAm) alterations have been implicated in both the aging processes and the development...
5.
Rodriguez-Blanco J, Salvador A, Suter R, Swiderska-Syn M, Palomo-Caturla I, Kliebe V, et al.
J Clin Invest
. 2024 Jun;
134(15).
PMID: 38885332
Most children with medulloblastoma (MB) achieve remission, but some face very aggressive metastatic tumors. Their dismal outcome highlights the critical need to advance therapeutic approaches that benefit such high-risk patients....
6.
Zhang W, Young J, Gomez L, Schmidt M, Lukacsovich D, Varma A, et al.
Epigenetics
. 2024 Apr;
19(1):2333660.
PMID: 38564759
DNA methylation (DNAm) plays a crucial role in a number of complex diseases. However, the reliability of DNAm levels measured using Illumina arrays varies across different probes. Previous research primarily...
7.
Chowdhury S, Kennedy J, Ivey R, Murillo O, Hosseini N, Song X, et al.
Cell
. 2024 Feb;
187(4):1016.
PMID: 38364782
No abstract available.
8.
Huang H, Wu C, Colaprico A, Bleu P, Zambare W, Alvarez J, et al.
medRxiv
. 2024 Feb;
PMID: 38352407
Rectal cancer (RC) presents significant treatment challenges, particularly in the context of chemotherapy resistance. Addressing this, our study pioneers the use of matched RC tumor tissue and patient-derived organoid (PDO)...
9.
Lu M, Yin R, Chen X
J Transl Med
. 2024 Feb;
22(1):140.
PMID: 38321494
Building Single Sample Predictors (SSPs) from gene expression profiles presents challenges, notably due to the lack of calibration across diverse gene expression measurement technologies. However, recent research indicates the viability...
10.
Lukacsovich D, OShea D, Huang H, Zhang W, Young J, Chen X, et al.
medRxiv
. 2023 Dec;
PMID: 38105943
Alzheimer's disease (AD) is a common neurodegenerative disorder with a significant impact on aging populations. DNA methylation (DNAm) alterations have been implicated in both the aging processes and the development...