Woo Jun Shim
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Explore the profile of Woo Jun Shim including associated specialties, affiliations and a list of published articles.
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9
Citations
64
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Recent Articles
1.
Shen S, Werner T, Lukowski S, Andersen S, Sun Y, Shim W, et al.
Nat Commun
. 2025 Feb;
16(1):1356.
PMID: 39904980
Pluripotent stem cells provide a scalable approach to analyse molecular regulation of cell differentiation across developmental lineages. Here, we engineer barcoded induced pluripotent stem cells to generate an atlas of...
2.
Zhao Q, Shim W, Sun Y, Sinniah E, Shen S, Boden M, et al.
Brief Bioinform
. 2025 Jan;
26(1.
PMID: 39800877
Regulatory genes are critical determinants of cellular responses in development and disease, but standard RNA sequencing (RNA-seq) analysis workflows, such as differential expression analysis, have significant limitations in revealing the...
3.
Hume R, Deshmukh T, Doan T, Shim W, Kanagalingam S, Tallapragada V, et al.
JACC Basic Transl Sci
. 2023 Jul;
8(6):658-674.
PMID: 37426530
After myocardial infarction (MI), fibroblasts progress from proliferative to myofibroblast states, resulting in fibrosis. Platelet-derived growth factors (PDGFs) are reported to induce fibroblast proliferation, myofibroblast differentiation, and fibrosis. However, we...
4.
Sun Y, Shim W, Shen S, Sinniah E, Pham D, Su Z, et al.
Nucleic Acids Res
. 2023 May;
51(11):e62.
PMID: 37125641
Methods for cell clustering and gene expression from single-cell RNA sequencing (scRNA-seq) data are essential for biological interpretation of cell processes. Here, we present TRIAGE-Cluster which uses genome-wide epigenetic data...
5.
Afonso J, Shim W, Boden M, Fortes M, Diniz W, de Lima A, et al.
Biochem Biophys Rep
. 2023 Jan;
33:101420.
PMID: 36654922
Epigenetic repression has been linked to the regulation of different cell states. In this study, we focus on the influence of this repression, mainly by H3K27me3, over gene expression in...
6.
Plaisance I, Chouvardas P, Sun Y, Nemir M, Aghagolzadeh P, Aminfar F, et al.
Cardiovasc Res
. 2022 Dec;
119(6):1361-1376.
PMID: 36537036
Aims: The major cardiac cell types composing the adult heart arise from common multipotent precursor cells. Cardiac lineage decisions are guided by extrinsic and cell-autonomous factors, including recently discovered long...
7.
Shen S, Sun Y, Matsumoto M, Shim W, Sinniah E, Wilson S, et al.
Trends Mol Med
. 2021 Oct;
27(12):1135-1158.
PMID: 34657800
Pluripotent stem cells underpin a growing sector that leverages their differentiation potential for research, industry, and clinical applications. This review evaluates the landscape of methods in single-cell transcriptomics that are...
8.
Chio U, Liu Y, Chung S, Shim W, Chandrasekar S, Weiss S, et al.
J Cell Biol
. 2021 Oct;
220(11).
PMID: 34614151
The guided entry of tail-anchored protein (GET) pathway, in which the Get3 ATPase delivers an essential class of tail-anchored membrane proteins (TAs) to the Get1/2 receptor at the endoplasmic reticulum,...
9.
Kojic M, Gawda T, Gaik M, Begg A, Salerno-Kochan A, Kurniawan N, et al.
Nat Commun
. 2021 May;
12(1):2678.
PMID: 33976153
Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common neurodevelopmental disorders and are characterized by substantial impairment in intellectual and adaptive functioning, with their genetic and molecular...
10.
Cho H, Shim W, Liu Y, Shan S
J Biol Chem
. 2021 Mar;
296:100546.
PMID: 33741343
J-domain proteins (JDPs) play essential roles in Hsp70 function by assisting Hsp70 in client trapping and regulating the Hsp70 ATPase cycle. Here, we report that JDPs can further enhance the...