Wondossen Sime
Overview
Explore the profile of Wondossen Sime including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
383
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Recent Articles
1.
Saamarthy K, Daams R, Sime W, Persson C, Chygorin E, Ahlqvist K, et al.
Br J Pharmacol
. 2025 Feb;
PMID: 39943627
Background And Purpose: Malignant melanoma is the most lethal form of skin cancer, characterised by a poor survival rate. One of the key factors driving the aggressive growth of melanoma...
2.
Daams R, Tran T, Jemaa M, Sime W, Mickeviciute R, Ek S, et al.
Cell Death Dis
. 2024 Sep;
15(9):690.
PMID: 39327470
The t(14;19)(q32;q13) is a rare recurring translocation found in B-cell lymphoproliferative malignancies, involving the Bcl-3 gene. This chromosomal translocation is often found in patients under the age of 50 and...
3.
Saamarthy K, Ahlqvist K, Daams R, Balagunaseelan N, Rinaldo-Matthis A, Kazi J, et al.
BMC Cancer
. 2024 Jan;
24(1):103.
PMID: 38238702
Molecular targeted therapy using a drug that suppresses the growth and spread of cancer cells via inhibition of a specific protein is a foundation of precision medicine and treatment. High...
4.
Shah K, Nasimian A, Ahmed M, Al Ashiri L, Denison L, Sime W, et al.
Blood Cancer J
. 2023 Sep;
13(1):139.
PMID: 37679323
The deregulation of BCL2 family proteins plays a crucial role in leukemia development. Therefore, pharmacological inhibition of this family of proteins is becoming a prevalent treatment method. However, due to...
5.
Grigoryan A, Zacharaki D, Balhuizen A, Come C, Garcia Garcia A, Hidalgo Gil D, et al.
Sci Transl Med
. 2022 Oct;
14(666):eabm6391.
PMID: 36223446
The bone marrow microenvironment provides indispensable factors to sustain blood production throughout life. It is also a hotspot for the progression of hematologic disorders and the most frequent site of...
6.
Serrano S, Tavecchio M, Gronberg A, Sime W, Jemaa M, Moss S, et al.
Cancers (Basel)
. 2021 Jul;
13(12).
PMID: 34207224
Hepatocellular carcinoma (HCC), the most common primary liver cancer, is usually diagnosed in its late state. Tyrosine kinase inhibitors such as sorafenib and regorafenib are one of the few treatment...
7.
Masoumi K, Huang X, Sime W, Mirkov A, Munksgaard Thoren M, Massoumi R, et al.
Cancers (Basel)
. 2021 Apr;
13(5).
PMID: 33803359
Glioblastoma (GB) is the most common and the most aggressive form of brain tumor in adults, which currently lacks efficient treatment strategies. In this study, we investigated the therapeutic effect...
8.
Jemaa M, Sime W, Abassi Y, Lasorsa V, Kohler J, Michaelis M, et al.
Int J Mol Sci
. 2020 Sep;
21(18).
PMID: 32948088
Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. Patients with relapsed disease have a poor prognosis despite intense treatment. In the present study, we aimed to identify...
9.
Sime W, Jemaa M, Abassi Y, Lasorsa V, Kohler J, Hansson K, et al.
Int J Mol Sci
. 2020 Sep;
21(18).
PMID: 32911859
Neuroblastoma is a childhood solid tumour originating from undifferentiated neural progenitor cells of the sympathetic nervous system. Drug resistance of childhood cancer neuroblastoma is a serious clinical problem. In the...
10.
Daams R, Sime W, Leandersson K, Sitnicka E, Massoumi R
J Immunol
. 2020 Aug;
205(7):1830-1841.
PMID: 32839237
The β-catenin/Wnt signaling pathway plays an important role in all stages of T cell development. Nemo-like kinase (NLK) is an evolutionary conserved serine/threonine kinase and a negative regulator of the...