Wojciech W Krajewski
Overview
Explore the profile of Wojciech W Krajewski including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
11
Citations
450
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Stockley M, Benedetti G, Blencowe P, Boulton S, Boyd S, Calder M, et al.
J Med Chem
. 2023 Feb;
PMID: 36815444
No abstract available.
2.
Stockley M, Ferdinand A, Benedetti G, Blencowe P, Boyd S, Calder M, et al.
J Med Chem
. 2022 Oct;
65(20):13879-13891.
PMID: 36200480
Human DNA polymerase theta (Polθ), which is essential for microhomology-mediated DNA double strand break repair, has been proposed as an attractive target for the treatment of BRCA deficient and other...
3.
Josue Ruiz E, Pinto-Fernandez A, Turnbull A, Lan L, Charlton T, Scott H, et al.
Elife
. 2021 Oct;
10.
PMID: 34636321
Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient's 5-year survival rate is...
4.
Turnbull A, Ioannidis S, Krajewski W, Pinto-Fernandez A, Heride C, Martin A, et al.
Nature
. 2017 Oct;
550(7677):481-486.
PMID: 29045389
Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to human diseases including cancer. Deubiquitinases remove ubiquitin from proteins, and their inhibition can induce the degradation of...
5.
Krajewski W, Fu X, Wilkinson M, Cronin N, Dillingham M, Wigley D
Nature
. 2014 Mar;
508(7496):416-9.
PMID: 24670664
In bacterial cells, processing of double-stranded DNA breaks for repair by homologous recombination is dependent upon the recombination hotspot sequence χ (Chi) and is catalysed by either an AddAB- or...
6.
Saikrishnan K, Yeeles J, Gilhooly N, Krajewski W, Dillingham M, Wigley D
EMBO J
. 2012 Feb;
31(6):1568-78.
PMID: 22307084
In bacterial cells, processing of double-stranded DNA breaks for repair by homologous recombination is dependent upon the recombination hotspot sequence Chi and is catalysed by either an AddAB- or RecBCD-type...
7.
Nilsson M, Krajewski W, Yellagunda S, Prabhumurthy S, Chamarahally G, Siddamadappa C, et al.
J Mol Biol
. 2009 Aug;
393(2):504-13.
PMID: 19695264
Glutamine synthetase (GS, EC 6.3.1.2; also known as gamma-glutamyl:ammonia ligase) catalyzes the ATP-dependent condensation of glutamate and ammonia to form glutamine. The enzyme has essential roles in different tissues and...
8.
Lagerlund O, Odell L, Mowbray S, Nilsson M, Krajewski W, Nordqvist A, et al.
Comb Chem High Throughput Screen
. 2008 May;
10(9):783-9.
PMID: 18478959
A microwave-enhanced, palladium-catalyzed protocol for the alpha-arylation of a protected glycine in neat water is described. This reaction proceeds rapidly, under non-inert conditions, to afford a range of phenylglycine derivatives...
9.
Nordqvist A, Nilsson M, Rottger S, Odell L, Krajewski W, Andersson C, et al.
Bioorg Med Chem
. 2008 May;
16(10):5501-13.
PMID: 18462943
A combination of a literature survey, structure-based virtual screening and synthesis of a small library was performed to identify hits to the potential antimycobacterial drug target, glutamine synthetase. The best...
10.
Krajewski W, Collins R, Holmberg-Schiavone L, Jones T, Karlberg T, Mowbray S
J Mol Biol
. 2007 Nov;
375(1):217-28.
PMID: 18005987
Glutamine synthetase (GS) catalyzes the ligation of glutamate and ammonia to form glutamine, with concomitant hydrolysis of ATP. In mammals, the activity eliminates cytotoxic ammonia, at the same time converting...