Wing Shun Li
Overview
Explore the profile of Wing Shun Li including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
23
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0
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Recent Articles
1.
Li W, Carter L, Almassalha L, Gong R, Pujadas-Liwag E, Kuo T, et al.
Sci Adv
. 2025 Jan;
11(4):eadp0855.
PMID: 39854464
Understanding chromatin organization requires integrating measurements of genome connectivity and physical structure. It is well established that cohesin is essential for TAD and loop connectivity features in Hi-C, but the...
2.
Almassalha L, Carignano M, Liwag E, Li W, Gong R, Acosta N, et al.
Sci Adv
. 2025 Jan;
11(2):eadq6652.
PMID: 39792661
In single cells, variably sized nanoscale chromatin structures are observed, but it is unknown whether these form a cohesive framework that regulates RNA transcription. Here, we demonstrate that the human...
3.
Frederick J, Virk R, Ye I, Almassalha L, Wodarcyk G, VanDerway D, et al.
bioRxiv
. 2024 Nov;
PMID: 39605341
Cancer cells exhibit a remarkable resilience to cytotoxic stress, often adapting through transcriptional changes linked to alterations in chromatin structure. In several types of cancer, these adaptations involve epigenetic modifications...
4.
Carignano M, Kroeger M, Almassalha L, Agrawal V, Li W, Pujadas-Liwag E, et al.
Elife
. 2024 Sep;
13.
PMID: 39331520
We propose the Self Returning Excluded Volume (SR-EV) model for the structure of chromatin based on stochastic rules and physical interactions. The SR-EV generate conformationally defined domains observed by single-cell...
5.
Acosta N, Gong R, Su Y, Frederick J, Medina K, Li W, et al.
bioRxiv
. 2024 Sep;
PMID: 39314277
Super-resolution microscopy has revolutionized our ability to visualize structures below the diffraction limit of conventional optical microscopy and is particularly useful for investigating complex biological targets like chromatin. Chromatin exhibits...
6.
Kant A, Guo Z, Vinayak V, Neguembor M, Li W, Agrawal V, et al.
Nat Commun
. 2024 May;
15(1):4338.
PMID: 38773126
In interphase nuclei, chromatin forms dense domains of characteristic sizes, but the influence of transcription and histone modifications on domain size is not understood. We present a theoretical model exploring...
7.
Carignano M, Kroger M, Almassalha L, Agrawal V, Li W, Pujadas-Liwag E, et al.
ArXiv
. 2024 Mar;
PMID: 38495560
We propose the Self Returning Excluded Volume (SR-EV) model for the structure of chromatin based on stochastic rules and physical interactions. The SR-EV generate conformationally-defined domains observed by single cell...
8.
Carignano M, Kroger M, Almassalha L, Agrawal V, Li W, Pujadas E, et al.
Res Sq
. 2023 Oct;
PMID: 37886531
We propose the Self Returning Excluded Volume (SR-EV) model for the structure of chromatin based on stochastic rules and physical interactions that is able to capture the observed behavior across...
9.
Alvarado W, Agrawal V, Li W, Dravid V, Backman V, de Pablo J, et al.
ACS Cent Sci
. 2023 Jul;
9(6):1200-1212.
PMID: 37396862
Scanning transmission electron microscopy tomography with ChromEM staining (ChromSTEM), has allowed for the three-dimensional study of genome organization. By leveraging convolutional neural networks and molecular dynamics simulations, we have developed...
10.
Li Y, Agrawal V, Virk R, Roth E, Li W, Eshein A, et al.
Sci Rep
. 2022 Jul;
12(1):12720.
PMID: 35882912
No abstract available.