Luay M Almassalha
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Explore the profile of Luay M Almassalha including associated specialties, affiliations and a list of published articles.
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26
Citations
644
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Recent Articles
1.
Almassalha L, Carignano M, Liwag E, Li W, Gong R, Acosta N, et al.
Sci Adv
. 2025 Jan;
11(2):eadq6652.
PMID: 39792661
In single cells, variably sized nanoscale chromatin structures are observed, but it is unknown whether these form a cohesive framework that regulates RNA transcription. Here, we demonstrate that the human...
2.
Frederick J, Virk R, Ye I, Almassalha L, Wodarcyk G, VanDerway D, et al.
bioRxiv
. 2024 Nov;
PMID: 39605341
Cancer cells exhibit a remarkable resilience to cytotoxic stress, often adapting through transcriptional changes linked to alterations in chromatin structure. In several types of cancer, these adaptations involve epigenetic modifications...
3.
Carignano M, Kroeger M, Almassalha L, Agrawal V, Li W, Pujadas-Liwag E, et al.
Elife
. 2024 Sep;
13.
PMID: 39331520
We propose the Self Returning Excluded Volume (SR-EV) model for the structure of chromatin based on stochastic rules and physical interactions. The SR-EV generate conformationally defined domains observed by single-cell...
4.
Shim A, Frederick J, Pujadas E, Kuo T, Ye I, Pritchard J, et al.
PLoS One
. 2024 May;
19(5):e0301000.
PMID: 38805476
As imaging techniques rapidly evolve to probe nanoscale genome organization at higher resolution, it is critical to consider how the reagents and procedures involved in sample preparation affect chromatin at...
5.
Pujadas Liwag E, Wei X, Acosta N, Carter L, Yang J, Almassalha L, et al.
Genome Biol
. 2024 Mar;
25(1):77.
PMID: 38519987
Background: B-type lamins are critical nuclear envelope proteins that interact with the three-dimensional genomic architecture. However, identifying the direct roles of B-lamins on dynamic genome organization has been challenging as...
6.
Almassalha L, Hirano I
Aliment Pharmacol Ther
. 2022 Sep;
56(7):1205-1206.
PMID: 36071014
No abstract available.
7.
Li Y, Eshein A, Virk R, Eid A, Wu W, Frederick J, et al.
Sci Adv
. 2021 Feb;
7(1).
PMID: 33523864
Extending across multiple length scales, dynamic chromatin structure is linked to transcription through the regulation of genome organization. However, no individual technique can fully elucidate this structure and its relation...
8.
Huang K, Li Y, Shim A, Virk R, Agrawal V, Eshein A, et al.
Sci Adv
. 2020 Jan;
6(2):eaay4055.
PMID: 31950084
With the textbook view of chromatin folding based on the 30-nm fiber being challenged, it has been proposed that interphase DNA has an irregular 10-nm nucleosome polymer structure whose folding...
9.
Virk R, Wu W, Almassalha L, Bauer G, Li Y, VanDerway D, et al.
Sci Adv
. 2020 Jan;
6(2):eaax6232.
PMID: 31934628
Three-dimensional supranucleosomal chromatin packing plays a profound role in modulating gene expression by regulating transcription reactions through mechanisms such as gene accessibility, binding affinities, and molecular diffusion. Here, we use...
10.
Shim A, Nap R, Huang K, Almassalha L, Matusda H, Backman V, et al.
Biophys J
. 2019 Dec;
118(9):2117-2129.
PMID: 31818468
The nuclear environment is highly crowded by biological macromolecules, including chromatin and mobile proteins, which alter the kinetics and efficiency of transcriptional machinery. These alterations have been described, both theoretically...