William R Kirkpatrick
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Explore the profile of William R Kirkpatrick including associated specialties, affiliations and a list of published articles.
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49
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1183
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Recent Articles
1.
Wiederhold N, Xu X, Wang A, Najvar L, Garvey E, Ottinger E, et al.
Antimicrob Agents Chemother
. 2018 Aug;
62(11).
PMID: 30104280
VT-1129 is a novel fungal enzyme-specific Cyp51 inhibitor with potent cryptococcal activity. Because of its long half-life (>6 days in mice) and our desire to quickly reach potent efficacy, we...
2.
Wiederhold N, Najvar L, Garvey E, Brand S, Xu X, Ottinger E, et al.
Antimicrob Agents Chemother
. 2018 Jul;
62(9).
PMID: 29987152
Cryptococcal meningitis is a significant cause of morbidity and mortality in immunocompromised patients. VT-1129 is a novel fungus-specific Cyp51 inhibitor with potent activity against species. Our objective was to evaluate...
3.
Mor V, Rella A, Farnoud A, Singh A, Munshi M, Bryan A, et al.
mBio
. 2018 Mar;
9(2).
PMID: 29535196
No abstract available.
4.
Maincent J, Najvar L, Kirkpatrick W, Huang S, Patterson T, Wiederhold N, et al.
Drug Dev Ind Pharm
. 2016 Sep;
43(2):264-274.
PMID: 27645428
Previously, modified release itraconazole in the form of a melt-extruded amorphous solid dispersion based on a pH dependent enteric polymer combined with hydrophilic additives (HME-ITZ), exhibited improved in vitro dissolution...
5.
Kadosh D, Najvar L, Bocanegra R, Olivo M, Kirkpatrick W, Wiederhold N, et al.
Antimicrob Agents Chemother
. 2016 Aug;
60(11):6703-6708.
PMID: 27572393
Candida albicans, normally found as a commensal in the gut, is a major human fungal pathogen responsible for both mucosal and systemic infections in a wide variety of immunocompromised individuals,...
6.
Wiederhold N, Kovanda L, Najvar L, Bocanegra R, Olivo M, Kirkpatrick W, et al.
Antimicrob Agents Chemother
. 2016 Jun;
60(9):5600-3.
PMID: 27324761
We evaluated the efficacy of isavuconazole against cryptococcal meningitis. Treatment with either oral isavuconazole (120 mg/kg and 240 mg/kg twice a day [BID]) or fluconazole as the positive control significantly...
7.
White P, Wiederhold N, Loeffler J, Najvar L, Melchers W, Herrera M, et al.
J Clin Microbiol
. 2016 Jan;
54(4):960-6.
PMID: 26791366
The EuropeanAspergillusPCR Initiative (EAPCRI) has provided recommendations for the PCR testing of whole blood (WB) and serum/plasma. It is important to test these recommended protocols on nonsimulated "in vivo" specimens...
8.
Mor V, Rella A, Farnoud A, Singh A, Munshi M, Bryan A, et al.
mBio
. 2015 Jun;
6(3):e00647.
PMID: 26106079
Unlabelled: Recent estimates suggest that >300 million people are afflicted by serious fungal infections worldwide. Current antifungal drugs are static and toxic and/or have a narrow spectrum of activity. Thus,...
9.
Wiederhold N, Najvar L, Matsumoto S, Bocanegra R, Herrera M, Wickes B, et al.
Antimicrob Agents Chemother
. 2015 Mar;
59(5):2875-81.
PMID: 25753643
ASP9726 is an investigational echinocandin with in vitro activity against Aspergillus species. We evaluated the pharmacokinetics and efficacy of this agent in an established guinea pig model of invasive pulmonary...
10.
Wiederhold N, Najvar L, Fothergill A, Bocanegra R, Olivo M, McCarthy D, et al.
Antimicrob Agents Chemother
. 2014 Dec;
59(2):1341-3.
PMID: 25451054
We evaluated the in vitro and in vivo activities of the investigational arylamidine T-2307 against echinocandin-resistant Candida albicans. T-2307 demonstrated potent in vitro activity, and daily subcutaneous doses between 0.75...