William N Charman
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Explore the profile of William N Charman including associated specialties, affiliations and a list of published articles.
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Articles
102
Citations
2992
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Recent Articles
1.
Riddy D, Kammoun H, Murphy A, Bosnyak-Gladovic S, De la Fuente Gonzalez R, Merlin J, et al.
BMJ Open Diabetes Res Care
. 2021 Nov;
9(2).
PMID: 34782333
Introduction: A potential role for the orphan G protein-coupled receptor, GPR21, in linking immune cell infiltration into tissues and obesity-induced insulin resistance has been proposed, although limited studies in mice...
2.
Begley C, Ashton M, Baell J, Bettess M, Brown M, Carter B, et al.
Sci Transl Med
. 2021 Sep;
13(612):eabd5524.
PMID: 34550729
Drug repurposing is promoted as a cost- and time-effective mechanism for providing new medicines. Often, however, there is insufficient consideration by academic researchers of the processes required to ensure that...
3.
Rueda P, Merlin J, Chimenti S, Feletou M, Paysant J, White P, et al.
Front Pharmacol
. 2021 Mar;
12:628060.
PMID: 33776771
Adenosine A receptors (AR) are a potential target for cardiac injury treatment due to their cardioprotective/antihypertrophic actions, but drug development has been hampered by on-target side effects such as bradycardia...
4.
Matsson P, Baranczewski P, Giacomini K, Andersson T, Palm J, Palm K, et al.
J Pharm Sci
. 2020 Oct;
110(1):2-11.
PMID: 33096136
This issue of the Journal of Pharmaceutical Sciences is dedicated to Professor Per Artursson and the groundbreaking contributions he has made and continues to make in the Pharmaceutical Sciences. Per...
5.
Trevaskis N, Lee G, Escott A, Phang K, Hong J, Cao E, et al.
Front Physiol
. 2020 Jul;
11:458.
PMID: 32670074
The intestinal lymphatic system transports fluid, immune cells, dietary lipids, and highly lipophilic drugs from the intestine to the systemic circulation. These transport functions are important to health and when...
6.
Riddy D, Cook A, Shackleford D, Pierce T, Mocaer E, Mannoury la Cour C, et al.
Neuropharmacology
. 2018 Oct;
144:244-255.
PMID: 30359639
The histamine H receptor is a G protein-coupled receptor (GPCR) drug target that is highly expressed in the CNS, where it acts as both an auto- and hetero-receptor to regulate...
7.
Diepenhorst N, Leach K, Keller A, Rueda P, Cook A, Pierce T, et al.
Br J Pharmacol
. 2018 May;
175(21):4095-4108.
PMID: 29714810
Background And Purpose: Strontium ranelate, a drug approved and until recently used for the treatment of osteoporosis, mediates its effects on bone at least in part via the calcium-sensing (CaS)...
8.
Haidar I, Harding I, Bowater I, Eldridge D, Charman W
Int J Pharm
. 2017 Jun;
528(1-2):524-535.
PMID: 28619452
We report on the successful incorporation of the antimalarial drug, halofantrine, into laboratory based soybean oil emulsions which were designed to mimic the commercially available parenteral fat emulsion, Intralipid. A...
9.
Dong Y, Wang X, Kamaraj S, Bulbule V, Chiu F, Chollet J, et al.
J Med Chem
. 2017 Jan;
60(7):2654-2668.
PMID: 28052200
Building on insights gained from the discovery of the antimalarial ozonide arterolane (OZ277), we now describe the structure-activity relationship (SAR) of the antimalarial ozonide artefenomel (OZ439). Primary and secondary amino...
10.
Diepenhorst N, Nowell C, Rueda P, Henriksen K, Pierce T, Cook A, et al.
Anal Biochem
. 2016 Dec;
519:51-56.
PMID: 27988276
Osteoclasts are multinuclear cells that degrade bone under both physiological and pathophysiological conditions. Osteoclasts are therefore a major target of osteoporosis therapeutics aimed at preserving bone. Consequently, analytical methods for...