William I Sivitz
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Explore the profile of William I Sivitz including associated specialties, affiliations and a list of published articles.
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62
Citations
1941
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Recent Articles
1.
Utzschneider K, Tripputi M, Butera N, Mari A, Rosin S, Banerji M, et al.
Diabetes Care
. 2025 Feb;
PMID: 39998948
Objective: To evaluate how model-based parameters of β-cell function change with glucose-lowering treatment and associate with glycemic deterioration in adults with type 2 diabetes (T2D). Research Design And Methods: In...
2.
Som R, Fink B, Rauckhorst A, Taylor E, Sivitz W
J Bioenerg Biomembr
. 2025 Feb;
PMID: 39954225
Glutamine is well recognized as critical to the growth of most cell types. Within mitochondria glutamine is converted to glutamate by glutaminase. Oxaloacetate and glutamate then react to form alpha-ketoglutarate...
3.
Som R, Fink B, Yu L, Sivitz W
Am J Physiol Cell Physiol
. 2024 Apr;
326(6):C1669-C1682.
PMID: 38646781
We previously showed that the transaminase inhibitor, aminooxyacetic acid, reduced respiration energized at complex II (succinate dehydrogenase, SDH) in mitochondria isolated from mouse hindlimb muscle. The effect required a reduction...
4.
Rasouli N, Younes N, Ghosh A, Albu J, Cohen R, DeFronzo R, et al.
Diabetes Care
. 2024 Jan;
47(4):580-588.
PMID: 38211595
Objective: To compare the long-term effects of glucose-lowering medications (insulin glargine U-100, glimepiride, liraglutide, and sitagliptin) when added to metformin on insulin sensitivity and β-cell function. Research Design And Methods:...
5.
Utzschneider K, Younes N, Butera N, Balasubramanyam A, Bergenstal R, Barzilay J, et al.
Diabetes Care
. 2024 Jan;
47(4):571-579.
PMID: 38190619
Objective: To compare the effects of insulin sensitivity and β-cell function over time on HbA1c and durability of glycemic control in response to dual therapy. Research Design And Methods: GRADE...
6.
Som R, Fink B, Yu L, Sivitz W
Am J Physiol Cell Physiol
. 2023 May;
324(6):C1236-C1248.
PMID: 37125774
We previously found that skeletal muscle mitochondria incubated at low membrane potential (ΔΨ) or interscapular brown adipose tissue (IBAT) mitochondria, wherein ΔΨ is intrinsically low, accumulate oxaloacetate (OAA) in amounts...
7.
Yu L, Fink B, Som R, Rauckhorst A, Taylor E, Sivitz W
Biochim Biophys Acta Bioenerg
. 2022 Oct;
1864(1):148930.
PMID: 36272463
At low inner mitochondrial membrane potential (ΔΨ) oxaloacetate (OAA) accumulates in the organelles concurrently with decreased complex II-energized respiration. This is consistent with ΔΨ-dependent OAA inhibition of succinate dehydrogenase. To...
8.
Braffett B, Bebu I, El Ghormli L, Cowie C, Sivitz W, Pop-Busui R, et al.
JAMA Netw Open
. 2022 Sep;
5(9):e2230710.
PMID: 36074461
Importance: The lower risk of cardiovascular disease (CVD) among women compared with men in the general population may be diminished among those with diabetes. Objective: To evaluate cardiometabolic risk factors...
9.
Fink B, Rauckhorst A, Taylor E, Yu L, Sivitz W
FASEB Bioadv
. 2022 Apr;
4(3):197-210.
PMID: 35392250
Classically, mitochondrial respiration responds to decreased membrane potential (ΔΨ) by increasing respiration. However, we found that for succinate-energized complex II respiration in skeletal muscle mitochondria (unencumbered by rotenone), low ΔΨ...
10.
Bhardwaj G, Penniman C, Jena J, Suarez Beltran P, Foster C, Poro K, et al.
J Clin Invest
. 2021 Aug;
131(18).
PMID: 34343133
Decreased skeletal muscle strength and mitochondrial dysfunction are characteristic of diabetes. The actions of insulin and IGF-1 through the insulin receptor (IR) and IGF-1 receptor (IGF1R) maintain muscle mass via...