William H Bunnelle
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Explore the profile of William H Bunnelle including associated specialties, affiliations and a list of published articles.
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27
Citations
380
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Recent Articles
1.
Horti A, Ravert H, Gao Y, Holt D, Bunnelle W, Schrimpf M, et al.
Nucl Med Biol
. 2013 Jan;
40(3):395-402.
PMID: 23294899
Introduction: α7-nicotinic acetylcholine receptor (α7-nAChR) is one of the major neuronal nAChR subtypes. α7-nAChR is involved in variety of neuronal processes and disorders including schizophrenia and Alzheimer's disease. A number...
2.
Schrimpf M, Sippy K, Briggs C, Anderson D, Li T, Ji J, et al.
Bioorg Med Chem Lett
. 2012 Jan;
22(4):1633-8.
PMID: 22281189
The well-known interferon-inducer tilorone was found to possess potent affinity for the agonist site of the α7 neuronal nicotinic receptor (K(i)=56 nM). SAR investigations determined that both basic sidechains are...
3.
Scanio M, Shi L, Bunnelle W, Anderson D, Helfrich R, Malysz J, et al.
J Med Chem
. 2011 Oct;
54(21):7678-92.
PMID: 21962147
A series of diazabicyclo[3.3.0]octane substituted pyridines and pyrazines was synthesized and characterized at the α4β2 neuronal nicotinic acetylcholine receptor (nAChR). The compounds were designed to mimic the profile of ABT-089,...
4.
Li J, Mathieu S, Harris R, Ji J, Anderson D, Malysz J, et al.
J Neuroimmunol
. 2011 Sep;
239(1-2):37-43.
PMID: 21911260
Immunological responses to protect against excessive inflammation can be regulated by the central nervous system through the cholinergic anti-inflammatory pathway wherein acetylcholine released from vagus nerves can inhibit inflammatory cytokines....
5.
Bunnelle W
J Org Chem
. 2011 May;
76(13):5429-32.
PMID: 21598979
Carbamyl glucuronidation is an increasingly well-recognized route of metabolism for secondary amine drugs. Proper characterization of these metabolites requires the synthesis of authentic standards. O-protected glucuronyl p-nitrophenyl carbonates can be...
6.
Malysz J, Anderson D, Gronlien J, Ji J, Bunnelle W, Hakerud M, et al.
J Pharmacol Exp Ther
. 2010 May;
334(3):863-74.
PMID: 20504915
Enhancement of alpha7 nicotinic acetylcholine receptor (nAChR) activity is considered a therapeutic approach for ameliorating cognitive deficits present in Alzheimer's disease and schizophrenia. In this study, we describe the in...
7.
Bitner R, Bunnelle W, Decker M, Drescher K, Kohlhaas K, Markosyan S, et al.
J Pharmacol Exp Ther
. 2010 May;
334(3):875-86.
PMID: 20504913
We previously reported that alpha7 nicotinic acetylcholine receptor (nAChR) agonism produces efficacy in preclinical cognition models correlating with activation of cognitive and neuroprotective signaling pathways associated with Alzheimer's disease (AD)...
8.
Li T, Bunnelle W, Ryther K, Anderson D, Malysz J, Helfrich R, et al.
Bioorg Med Chem Lett
. 2010 May;
20(12):3636-9.
PMID: 20472430
Biaryl substituted 2,5-diazabicyclo[2.2.1]heptanes have been synthesized and tested for their affinity toward alpha7 neuronal nicotinic receptors (NNRs). SAR studies established that 5-N-methyl substituent, heteroaryl linker and the nature of terminal...
9.
Mortell K, Schrimpf M, Bunnelle W, Anderson D, Gronlien J, Hagene K, et al.
Bioorg Med Chem Lett
. 2009 Dec;
20(1):104-7.
PMID: 19954975
A series of alpha7 neuronal nicotinic acetylcholine receptor ligands were designed based on a structural combination of a potent, but non-selective ligand, epibatidine, with a selective lead structure, 2. Three...
10.
Briggs C, Gronlien J, Curzon P, Timmermann D, Ween H, Thorin-Hagene K, et al.
Br J Pharmacol
. 2009 Oct;
158(6):1486-94.
PMID: 19845675
Background And Purpose: Several agonists of the alpha7 nicotinic acetylcholine receptor (nAChR) have been developed for treatment of cognitive deficits. However, agonist efficacy in vivo is difficult to reconcile with...