William Doherty
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Explore the profile of William Doherty including associated specialties, affiliations and a list of published articles.
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21
Citations
161
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Recent Articles
1.
Doherty W, Conway L, Leveau B, Giulia Nacca F, Chiappa L, Riccio A, et al.
ChemMedChem
. 2024 Dec;
:e202400823.
PMID: 39648152
Inspired by the cyclopentenone family of prostaglandins, a series of 4-aza, cross-conjugated cyclopentenones is described. Synthesised from N-protected (4R)-aza-cyclopentenone 5, the exocyclic alkene was installed using a modified Baylis-Hillman type...
2.
Berney M, Fay E, Doherty W, Deering J, Durr E, Ferguson S, et al.
Chembiochem
. 2024 Jul;
25(21):e202400528.
PMID: 39023512
A series of chemically-modified oligonucleotides for targeting the DNA repair nuclease SNM1A have been designed and synthesised. Each oligonucleotide contains a modified internucleotide linkage designed to both mimic the native...
3.
Doherty W, Benson S, Pepdjonovic L, Koppes A, Koppes R
ACS Biomater Sci Eng
. 2024 Feb;
10(3):1880-1891.
PMID: 38374716
Giant plasma membrane vesicles (GPMVs) have been utilized as a model to study phase separation in the plasma membrane. Additionally, GPMVs have been employed as vehicle for delivering molecular cargo,...
4.
Babadi A, Rahmati S, Fakhlaei R, Heidari R, Baradaran S, Akbariqomi M, et al.
Sci Rep
. 2022 Nov;
12(1):19416.
PMID: 36371566
The current COVID-19 pandemic outbreak poses a serious threat to public health, demonstrating the critical need for the development of effective and reproducible detection tests. Since the RT-qPCR primers are...
5.
Berney M, Doherty W, Jauslin W, Manoj M, Durr E, McGouran J
Bioorg Med Chem
. 2021 Sep;
46:116369.
PMID: 34482229
SNM1A is a zinc-dependent nuclease involved in the removal of interstrand crosslink lesions from DNA. Inhibition of interstrand crosslink repair enzymes such as SNM1A is a promising strategy for improving...
6.
Rahmati S, Doherty W, Babadi A, Akmal Che Mansor M, Muhd Julkapli N, Hessel V, et al.
Micromachines (Basel)
. 2021 Jul;
12(6).
PMID: 34205255
The environmental crisis, due to the rapid growth of the world population and globalisation, is a serious concern of this century. Nanoscience and nanotechnology play an important role in addressing...
7.
Doherty W, Adler N, Butler T, Knox A, Evans P
Bioorg Med Chem
. 2020 Sep;
28(23):115774.
PMID: 32992251
A series of lysine-based vinyl sulfone peptidomimetics were synthesised and evaluated for anti-trypanosomal activity against bloodstream forms of T. brucei. This focused set of compounds, varying in the P position,...
8.
Zhou R, Zhou R, Zhang X, Fang Z, Wang X, Speight R, et al.
ChemSusChem
. 2019 Aug;
12(22):4976-4985.
PMID: 31441585
Conversion of renewable biomass by time- and energy-efficient techniques remains an important challenge. Herein, plasma catalytic liquefaction (PCL) is employed to achieve rapid liquefaction of microalgae under mild conditions. The...
9.
Durr E, Doherty W, Lee S, El-Sagheer A, Shivalingam A, McHugh P, et al.
ChemistrySelect
. 2019 Aug;
3(45):12824-12829.
PMID: 31414040
Phosphate groups are often crucial to biological activity and interactions of oligonucleotides, but confer poor membrane permeability. In addition, the group's lability to enzymatic hydrolysis is an obstacle to its...
10.
Doherty W, Durr E, Baddock H, Lee S, McHugh P, Brown T, et al.
Org Biomol Chem
. 2019 Aug;
17(35):8094-8105.
PMID: 31380542
Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate...