William C Wright
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Explore the profile of William C Wright including associated specialties, affiliations and a list of published articles.
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23
Citations
241
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Recent Articles
1.
Pan M, Zhang Y, Wright W, Liu X, Passaia B, Currier D, et al.
Nat Commun
. 2025 Feb;
16(1):2036.
PMID: 40021625
Retinoic acid (RA) is a standard-of-care neuroblastoma drug thought to be effective by inducing differentiation. Curiously, RA has little effect on primary human tumors during upfront treatment but can eliminate...
2.
Ansari S, Dillard M, Ghonim M, Zhang Y, Stewart D, Canac R, et al.
bioRxiv
. 2025 Feb;
PMID: 39975106
Sonic Hedgehog (SHH) signaling functions in temporal- and context-dependent manners to pattern diverse tissues during embryogenesis. The signal transducer Smoothened (SMO) is activated by sterols, oxysterols, and arachidonic acid (AA)...
3.
Liu X, Chapple R, Bennett D, Wright W, Sanjali A, Culp E, et al.
Cell Genom
. 2025 Jan;
5(1):100739.
PMID: 39788105
Exploratory analysis of single-cell RNA sequencing (scRNA-seq) typically relies on hard clustering over two-dimensional projections like uniform manifold approximation and projection (UMAP). However, such methods can severely distort the data...
4.
Chapple R, Liu X, Natarajan S, Alexander M, Kim Y, Patel A, et al.
Genome Biol
. 2024 Jun;
25(1):161.
PMID: 38898465
Background: Neuroblastoma is a common pediatric cancer, where preclinical studies suggest that a mesenchymal-like gene expression program contributes to chemotherapy resistance. However, clinical outcomes remain poor, implying we need a...
5.
Pan M, Zhang Y, Wright W, Liu X, Passaia B, Currier D, et al.
bioRxiv
. 2024 May;
PMID: 38798584
Retinoic acid (RA) is a standard-of-care neuroblastoma drug thought to be effective by inducing differentiation. Curiously, RA has little effect on primary human tumors during upfront treatment but can eliminate...
6.
Chapple R, Liu X, Natarajan S, Alexander M, Kim Y, Patel A, et al.
bioRxiv
. 2024 May;
PMID: 38712039
Neuroblastoma is a common pediatric cancer, where preclinical studies suggest that a mesenchymal-like gene expression program contributes to chemotherapy resistance. However, clinical outcomes remain poor, implying we need a better...
7.
Shao M, Pan Q, Tan H, Wu J, Lee H, Huber A, et al.
Genes Dis
. 2024 Apr;
11(4):101079.
PMID: 38560501
CYP3A5 is a cytochrome P450 (CYP) enzyme that metabolizes drugs and contributes to drug resistance in cancer. However, it remains unclear whether CYP3A5 directly influences cancer progression. In this report,...
8.
Lee H, Wright W, Pan M, Low J, Currier D, Fang J, et al.
Nat Commun
. 2023 Nov;
14(1):7332.
PMID: 37957169
Combination chemotherapy is crucial for successfully treating cancer. However, the enormous number of possible drug combinations means discovering safe and effective combinations remains a significant challenge. To improve this process,...
9.
Kamens J, Nance S, Koss C, Xu B, Cotton A, Lam J, et al.
Nat Commun
. 2023 Mar;
14(1):1297.
PMID: 36894563
No abstract available.
10.
Kamens J, Nance S, Koss C, Xu B, Cotton A, Lam J, et al.
Nat Commun
. 2023 Feb;
14(1):809.
PMID: 36781850
Rearrangments in Histone-lysine-N-methyltransferase 2A (KMT2Ar) are associated with pediatric, adult and therapy-induced acute leukemias. Infants with KMT2Ar acute lymphoblastic leukemia (ALL) have a poor prognosis with an event-free-survival of 38%....