Richard H Chapple
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Explore the profile of Richard H Chapple including associated specialties, affiliations and a list of published articles.
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14
Citations
403
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Recent Articles
1.
Pan M, Zhang Y, Wright W, Liu X, Passaia B, Currier D, et al.
Nat Commun
. 2025 Feb;
16(1):2036.
PMID: 40021625
Retinoic acid (RA) is a standard-of-care neuroblastoma drug thought to be effective by inducing differentiation. Curiously, RA has little effect on primary human tumors during upfront treatment but can eliminate...
2.
Liu X, Chapple R, Bennett D, Wright W, Sanjali A, Culp E, et al.
Cell Genom
. 2025 Jan;
5(1):100739.
PMID: 39788105
Exploratory analysis of single-cell RNA sequencing (scRNA-seq) typically relies on hard clustering over two-dimensional projections like uniform manifold approximation and projection (UMAP). However, such methods can severely distort the data...
3.
Chapple R, Liu X, Natarajan S, Alexander M, Kim Y, Patel A, et al.
Genome Biol
. 2024 Jun;
25(1):161.
PMID: 38898465
Background: Neuroblastoma is a common pediatric cancer, where preclinical studies suggest that a mesenchymal-like gene expression program contributes to chemotherapy resistance. However, clinical outcomes remain poor, implying we need a...
4.
Pan M, Zhang Y, Wright W, Liu X, Passaia B, Currier D, et al.
bioRxiv
. 2024 May;
PMID: 38798584
Retinoic acid (RA) is a standard-of-care neuroblastoma drug thought to be effective by inducing differentiation. Curiously, RA has little effect on primary human tumors during upfront treatment but can eliminate...
5.
Chapple R, Liu X, Natarajan S, Alexander M, Kim Y, Patel A, et al.
bioRxiv
. 2024 May;
PMID: 38712039
Neuroblastoma is a common pediatric cancer, where preclinical studies suggest that a mesenchymal-like gene expression program contributes to chemotherapy resistance. However, clinical outcomes remain poor, implying we need a better...
6.
Patel A, Ashenberg O, Collins N, Segerstolpe A, Jiang S, Slyper M, et al.
bioRxiv
. 2024 Jan;
PMID: 38260392
Neuroblastoma is a pediatric cancer arising from the developing sympathoadrenal lineage with complex inter- and intra-tumoral heterogeneity. To chart this complexity, we generated a comprehensive cell atlas of 55 neuroblastoma...
7.
Lee H, Wright W, Pan M, Low J, Currier D, Fang J, et al.
Nat Commun
. 2023 Nov;
14(1):7332.
PMID: 37957169
Combination chemotherapy is crucial for successfully treating cancer. However, the enormous number of possible drug combinations means discovering safe and effective combinations remains a significant challenge. To improve this process,...
8.
Zubair A, Chapple R, Natarajan S, Wright W, Pan M, Lee H, et al.
Nucleic Acids Res
. 2022 May;
50(14):e80.
PMID: 35536287
Spatial transcriptomics technologies have recently emerged as a powerful tool for measuring spatially resolved gene expression directly in tissues sections, revealing cell types and their dysfunction in unprecedented detail. However,...
9.
Pan M, Wright W, Chapple R, Zubair A, Sandhu M, Batchelder J, et al.
Nat Commun
. 2021 Nov;
12(1):6468.
PMID: 34753908
Survival in high-risk pediatric neuroblastoma has remained around 50% for the last 20 years, with immunotherapies and targeted therapies having had minimal impact. Here, we identify the small molecule CX-5461...
10.
Takahashi M, Barile M, Chapple R, Tseng Y, Nakada D, Busch K, et al.
Stem Cell Reports
. 2021 Mar;
16(4):741-753.
PMID: 33770496
Hematopoiesis serves as a paradigm for how homeostasis is maintained within hierarchically organized cell populations. However, important questions remain as to the contribution of hematopoietic stem cells (HSCs) toward maintaining...