William C Trenkle
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Explore the profile of William C Trenkle including associated specialties, affiliations and a list of published articles.
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10
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130
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Recent Articles
1.
Evans D, Beiger J, Burch J, Fuller P, Glorius F, Kattnig E, et al.
J Am Chem Soc
. 2022 Oct;
144(43):19953-19972.
PMID: 36269121
The total syntheses of aflastatin A and its C3-C48 degradation fragment (, R = H) have been accomplished. The syntheses feature several complex diastereoselective fragment couplings, including a Felkin-selective trityl-catalyzed...
2.
Park S, Ahmad F, Bahde R, Philp A, Kim J, Huang T, et al.
PLoS One
. 2021 Jun;
16(6):e0253269.
PMID: 34138962
AMP-activated protein kinase (AMPK) is an evolutionarily conserved energy sensor. Activation of AMPK leads to a number of metabolic benefits, including improved mitochondrial function in skeletal muscle and lowering of...
3.
Bahde R, Appella D, Trenkle W
Tetrahedron Lett
. 2011 Sep;
52(32):4103-4105.
PMID: 21931465
The HIV-1 nucleocapsid (NCp7), structurally defined by zinc-binding domains, participates in crucial stages of the HIV-1 lifecycle and is mutationally nonpermissive, making it an attractive anti-HIV target. Mode of action...
4.
Bhattacharjee A, Lang L, Jacobson O, Shinkre B, Ma Y, Niu G, et al.
Nucl Med Biol
. 2011 Aug;
38(6):897-906.
PMID: 21843786
Introduction: A(2A) receptors are expressed in the basal ganglia, specifically in striatopallidal GABAergic neurons in the striatum (caudate-putamen). This brain region undergoes degeneration of presynaptic dopamine projections and depletion of...
5.
Wang Q, Shinkre B, Lee J, Weniger M, Liu Y, Chen W, et al.
PLoS One
. 2010 Dec;
5(11):e15479.
PMID: 21124757
Background: Protein homeostasis in the endoplasmic reticulum (ER) has recently emerged as a therapeutic target for cancer treatment. Disruption of ER homeostasis results in ER stress, which is a major...
6.
Shinkre B, Kumar T, Gao Z, Deflorian F, Jacobson K, Trenkle W
Bioorg Med Chem Lett
. 2010 Aug;
20(19):5690-4.
PMID: 20801028
Movement disorders such as Parkinson's disease and Huntington's disease are serious life-limiting and debilitating movement disorders. Their onset typically occurs from mid-life to late in life, and effective diagnostic techniques...
7.
Ji Y, Trenkle W, Vowles J
Org Lett
. 2006 Mar;
8(6):1161-3.
PMID: 16524293
[reaction: see text] beta-Ketonitriles are important precursors for a wide variety of biologically active heterocycles. A facile procedure for the high-yielding acylation of nitrile anions with unactivated esters to provide...
8.
Evans D, Trenkle W, Zhang J, Burch J
Org Lett
. 2005 Jul;
7(15):3335-8.
PMID: 16018654
[reaction: see text]. The C(8)-C(18) ethyl ketone and C(19)-C(28) aldehyde aflastatin A fragments were synthesized and coupled using a diastereoselective anti aldol reaction. This adduct was successfully converted into the...
9.
Barkin J, Faust Jr M, Trenkle W
Org Lett
. 2003 Aug;
5(18):3333-5.
PMID: 12943420
[reaction: see text] A Thorpe condensation is the key bond construction in a rapid and efficient synthesis of substituted cytosine derivatives from readily available starting materials.
10.
Belanger G, Hong F, Overman L, Rogers B, Tellew J, Trenkle W
J Org Chem
. 2002 Oct;
67(22):7880-3.
PMID: 12398520
The construction of triazacyclopenta[cd]pentalene diesters 6 by the reaction of dihydropyrrole alpha-ketoesters 3 with acylated hydrazines was evaluated further as a potential central strategic step in the total syntheses of...