William C Merrick
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Explore the profile of William C Merrick including associated specialties, affiliations and a list of published articles.
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3743
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Recent Articles
11.
Merrick W
N Biotechnol
. 2016 Sep;
38(Pt A):26-28.
PMID: 27664793
Over the past 50 years, both Brian Clark and I have worked on tRNA, Brian more successfully than I. Our common interests have established collaborations and the training of Aarhus...
12.
Barth-Baus D, Bhasker C, Zoll W, Merrick W
Translation (Austin)
. 2016 Jan;
1(1):e24419.
PMID: 26824019
Current literature using biochemical assays, structural analyses and genetic manipulations has reported that the key factors associated with the faithful matching of the initiator met-tRNA to the start codon AUG...
13.
Carelli J, Sethofer S, Smith G, Miller H, Simard J, Merrick W, et al.
Elife
. 2015 Dec;
4.
PMID: 26651998
Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we...
14.
Merrick W
J Biol Chem
. 2015 Sep;
290(40):24091-9.
PMID: 26324716
The original purification of the heterotrimeric eIF4F was published over 30 years ago (Grifo, J. A., Tahara, S. M., Morgan, M. A., Shatkin, A. J., and Merrick, W. C. (1983)...
15.
Chen H, Song R, Wang G, Ding Z, Yang C, Zhang J, et al.
Sci Rep
. 2015 Aug;
5:13241.
PMID: 26283179
Translation is a fundamental cellular process, and its dysregulation can contribute to human diseases such as cancer. During translation initiation the eukaryotic initiation factor 2 (eIF2) forms a ternary complex...
16.
Khan M, Ma J, Walden W, Merrick W, Theil E, Goss D
Nucleic Acids Res
. 2014 Apr;
42(10):6567-77.
PMID: 24728987
Metal ion binding was previously shown to destabilize IRE-RNA/IRP1 equilibria and enhanced IRE-RNA/eIF4F equilibria. In order to understand the relative importance of kinetics and stability, we now report rapid rates...
17.
Guan B, Krokowski D, Majumder M, Schmotzer C, Kimball S, Merrick W, et al.
J Biol Chem
. 2014 Mar;
289(18):12593-611.
PMID: 24648524
The accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) causes stress to which an unfolded protein response is activated to render cell survival or apoptosis (chronic stress). Transcriptional and...
18.
Merrick W, Harris M
EMBO J
. 2013 Dec;
33(1):3-4.
PMID: 24363142
Initiation is often assumed to be rate-limiting for protein synthesis, but the presence of rare codons nonetheless can influence protein levels. In this issue of The EMBO Journal, Chu et...
19.
Ma J, Haldar S, Khan M, Das Sharma S, Merrick W, Theil E, et al.
Proc Natl Acad Sci U S A
. 2012 May;
109(22):8417-22.
PMID: 22586079
Iron increases synthesis rates of proteins encoded in iron-responsive element (IRE)-mRNAs; metabolic iron ("free," "labile") is Fe(2+). The noncoding IRE-RNA structure, approximately 30 nt, folds into a stem loop to...
20.
Bentley A, Merkulov S, Peng Y, Rozmarynowycz R, Qi X, Pusztai-Carey M, et al.
J Biol Chem
. 2012 May;
287(26):22142-50.
PMID: 22577144
The study of synthetic peptides corresponding to discrete regions of proteins has facilitated the understanding of protein structure-activity relationships. Short peptides can also be used as powerful therapeutic agents. However,...