William C Horne
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Explore the profile of William C Horne including associated specialties, affiliations and a list of published articles.
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1232
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Recent Articles
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Kiviranta R, Yamana K, Saito H, Ho D, Laine J, Tarkkonen K, et al.
J Exp Med
. 2013 Apr;
210(5):969-85.
PMID: 23569325
Bone homeostasis is maintained by the coupled actions of hematopoietic bone-resorbing osteoclasts (OCs) and mesenchymal bone-forming osteoblasts (OBs). Here we identify early B cell factor 1 (Ebf1) and the transcriptional...
3.
Lotinun S, Kiviranta R, Matsubara T, Alzate J, Neff L, Luth A, et al.
J Clin Invest
. 2013 Jan;
123(2):666-81.
PMID: 23321671
Cathepsin K (CTSK) is secreted by osteoclasts to degrade collagen and other matrix proteins during bone resorption. Global deletion of Ctsk in mice decreases bone resorption, leading to osteopetrosis, but...
4.
Rowe G, Vialou V, Sato K, Saito H, Yin M, Green T, et al.
J Bone Miner Res
. 2012 Mar;
27(8):1649-58.
PMID: 22461201
The regulation of bone and fat homeostasis and its relationship to energy expenditure has recently been the focus of increased attention because of its potential relevance to osteoporosis, obesity, and...
5.
Marzia M, Guaiquil V, Horne W, Blobel C, Baron R, Chiusaroli R
Biol Chem
. 2011 Aug;
392(10):877-85.
PMID: 21801086
The ADAMs (a disintegrin and metalloprotease) contribute to various biological functions including the development of tissues by taking part in cell-cell and cell-matrix interactions. We previously found that ADAM15 is...
6.
Lotinun S, Pearsall R, Horne W, Baron R
Curr Mol Pharmacol
. 2011 Jul;
5(2):195-204.
PMID: 21787285
Current antiresorptive therapies not only prevent bone loss by decreasing osteoclastic bone resorption but also inhibit bone formation. Dual anabolic antiresorptive agents may be required to cure severe osteoporosis by...
7.
Hesse E, Saito H, Kiviranta R, Correa D, Yamana K, Neff L, et al.
J Cell Biol
. 2010 Dec;
191(7):1271-83.
PMID: 21173110
Runx2 is indispensable for osteoblast lineage commitment and early differentiation but also blocks osteoblast maturation, thereby causing bone loss in Runx2 transgenic mice. Zinc finger protein 521 (Zfp521) antagonizes Runx2...
8.
Correa D, Hesse E, Seriwatanachai D, Kiviranta R, Saito H, Yamana K, et al.
Dev Cell
. 2010 Oct;
19(4):533-46.
PMID: 20951345
In the growth plate, the interplay between parathyroid hormone-related peptide (PTHrP) and Indian hedgehog (Ihh) signaling tightly regulates chondrocyte proliferation and differentiation during longitudinal bone growth. We found that PTHrP...
9.
Purev E, Neff L, Horne W, Baron R
Mol Biol Cell
. 2009 Jul;
20(18):4021-30.
PMID: 19641021
c-Cbl and Cbl-b are highly conserved adaptor proteins that participate in integrin signaling, regulating cytoskeletal organization, motility, and bone resorption. Deletion of both c-Cbl and Cbl-b in mice leads to...
10.
Bruzzaniti A, Neff L, Sandoval A, Du L, Horne W, Baron R
Mol Cell Biol
. 2009 Apr;
29(13):3644-56.
PMID: 19380485
Signaling via the Pyk2-Src-Cbl complex downstream of integrins contributes to the assembly, organization, and dynamics of podosomes, which are the transient adhesion complexes of highly motile cells such as osteoclasts...