William B Hamilton
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Explore the profile of William B Hamilton including associated specialties, affiliations and a list of published articles.
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11
Citations
464
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Recent Articles
1.
Ngo L, Bert A, Dredge B, Williams T, Murphy V, Li W, et al.
Nature
. 2024 Mar;
627(8005):E12.
PMID: 38480896
No abstract available.
2.
Ngo L, Bert A, Dredge B, Williams T, Murphy V, Li W, et al.
Nature
. 2024 Feb;
627(8002):212-220.
PMID: 38355801
Circular RNAs (circRNAs), which are increasingly being implicated in a variety of functions in normal and cancerous cells, are formed by back-splicing of precursor mRNAs in the nucleus. circRNAs are...
3.
Knudsen T, Hamilton W, Proks M, Lykkegaard M, Linneberg-Agerholm M, Nielsen A, et al.
Cell Syst
. 2023 Aug;
14(9):788-805.e8.
PMID: 37633265
Cooperative DNA binding of transcription factors (TFs) integrates the cellular context to support cell specification during development. Naive mouse embryonic stem cells are derived from early development and can sustain...
4.
Narita T, Ito S, Higashijima Y, Chu W, Neumann K, Walter J, et al.
Mol Cell
. 2021 Mar;
81(10):2166-2182.e6.
PMID: 33765415
The metazoan-specific acetyltransferase p300/CBP is involved in activating signal-induced, enhancer-mediated transcription of cell-type-specific genes. However, the global kinetics and mechanisms of p300/CBP activity-dependent transcription activation remain poorly understood. We performed...
5.
Hamilton W, Mosesson Y, Monteiro R, Emdal K, Knudsen T, Francavilla C, et al.
Nature
. 2019 Nov;
575(7782):355-360.
PMID: 31695196
Central to understanding cellular behaviour in multi-cellular organisms is the question of how a cell exits one transcriptional state to adopt and eventually become committed to another. Fibroblast growth factor-extracellular...
6.
Laing A, Tirumala V, Hegarty E, Mondal S, Zhao P, Hamilton W, et al.
Biomicrofluidics
. 2019 Sep;
13(5):054102.
PMID: 31558920
Long-term, time-lapse imaging studies of embryonic stem cells (ESCs) require a controlled and stable culturing environment for high-resolution imaging. Microfluidics is well-suited for such studies, especially when the media composition...
7.
Weinert B, Narita T, Satpathy S, Srinivasan B, Hansen B, Scholz C, et al.
Cell
. 2018 May;
174(1):231-244.e12.
PMID: 29804834
The acetyltransferases CBP and p300 are multifunctional transcriptional co-activators. Here, we combined quantitative proteomics with CBP/p300-specific catalytic inhibitors, bromodomain inhibitor, and gene knockout to reveal a comprehensive map of regulated...
8.
Anderson K, Hamilton W, Roske F, Azad A, Knudsen T, Canham M, et al.
Nat Cell Biol
. 2017 Sep;
19(10):1164-1177.
PMID: 28945231
Signalling downstream of Activin/Nodal (ActA) and Wnt can induce endoderm differentiation and also support self-renewal in pluripotent cells. Here we find that these apparently contradictory activities are fine-tuned by insulin....
9.
Hamilton W, Brickman J
Cell Stem Cell
. 2017 Jan;
20(1):3-5.
PMID: 28061352
The precise place and time where embryonic differentiation begins is regulated by regionalized signaling. In this issue of Cell Stem Cell, Wang et al. (2017) investigate how converging Wnt and...
10.
Hamilton W, Brickman J
Cell Rep
. 2014 Dec;
9(6):2056-70.
PMID: 25533345
Fgf signaling via Erk activation has been associated with both neural induction and the generation of a primed state for the differentiation of embryonic stem cells (ESCs) to all somatic...