Jeffrey A Chao
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Explore the profile of Jeffrey A Chao including associated specialties, affiliations and a list of published articles.
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48
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2205
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Recent Articles
1.
Williams T, Michalak E, Carey K, Lam E, Anderson A, Griesbach E, et al.
Mol Cell
. 2025 Jan;
85(1):117-131.e7.
PMID: 39753105
Several transcription inhibitors have been developed as cancer therapies. However, they show modest clinical activity, highlighting that our understanding of the cellular response to transcriptional inhibition remains incomplete. Here we...
2.
Ngo L, Bert A, Dredge B, Williams T, Murphy V, Li W, et al.
Nature
. 2024 Mar;
627(8005):E12.
PMID: 38480896
No abstract available.
3.
Hochstoeger T, Papasaikas P, Piskadlo E, Chao J
Sci Adv
. 2024 Feb;
10(7):eadi7830.
PMID: 38363833
A central mechanism of mTOR complex 1 (mTORC1) signaling is the coordinated translation of ribosomal protein and translation factor mRNAs mediated by the 5'-terminal oligopyrimidine motif (5'TOP). Recently, La-related protein...
4.
Ngo L, Bert A, Dredge B, Williams T, Murphy V, Li W, et al.
Nature
. 2024 Feb;
627(8002):212-220.
PMID: 38355801
Circular RNAs (circRNAs), which are increasingly being implicated in a variety of functions in normal and cancerous cells, are formed by back-splicing of precursor mRNAs in the nucleus. circRNAs are...
5.
Eichenberger B, Griesbach E, Mitchell J, Chao J
Annu Rev Cell Dev Biol
. 2023 Oct;
39:253-275.
PMID: 37843928
Recent advances in single-molecule imaging of mRNAs in fixed and living cells have enabled the lives of mRNAs to be studied with unprecedented spatial and temporal detail. These approaches have...
6.
Hochstoeger T, Chao J
Semin Cell Dev Biol
. 2023 Jun;
154(Pt B):99-104.
PMID: 37316417
Vertebrate cells have evolved a simple, yet elegant, mechanism for coordinated regulation of ribosome biogenesis mediated by the 5' terminal oligopyrimidine motif (5'TOP). This motif allows cells to rapidly adapt...
7.
Vatandaslar H, Garzia A, Meyer C, Godbersen S, Brandt L, Griesbach E, et al.
Nat Commun
. 2023 Jun;
14(1):3386.
PMID: 37296170
System-wide cross-linking and immunoprecipitation (CLIP) approaches have unveiled regulatory mechanisms of RNA-binding proteins (RBPs) mainly in cultured cells due to limitations in the cross-linking efficiency of tissues. Here, we describe...
8.
Dave P, Roth G, Griesbach E, Mateju D, Hochstoeger T, Chao J
Mol Cell
. 2023 Feb;
83(4):589-606.e6.
PMID: 36731471
The relationship between mRNA translation and decay is incompletely understood, with conflicting reports suggesting that translation can either promote decay or stabilize mRNAs. The effect of translation on mRNA decay...
9.
Piskadlo E, Eichenberger B, Giorgetti L, Chao J
Methods Mol Biol
. 2022 Jul;
2537:173-183.
PMID: 35895264
Visualization of single mRNA molecules in fixed cells can be achieved using single molecule fluorescent in situ hybridization (smFISH). This approach enables accurate quantification of mRNA numbers and localization at...
10.
Zinnall U, Milek M, Minia I, Vieira-Vieira C, Muller S, Mastrobuoni G, et al.
Nat Commun
. 2022 May;
13(1):2727.
PMID: 35585045
The biological role of RNA-binding proteins in the secretory pathway is not well established. Here, we describe that human HDLBP/Vigilin directly interacts with more than 80% of ER-localized mRNAs. PAR-CLIP...