Chunaram Choudhary
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Explore the profile of Chunaram Choudhary including associated specialties, affiliations and a list of published articles.
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87
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11029
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Recent Articles
1.
Liebner T, Kilic S, Walter J, Aibara H, Narita T, Choudhary C
Nat Commun
. 2024 Jun;
15(1):4962.
PMID: 38862536
In all eukaryotes, acetylation of histone lysine residues correlates with transcription activation. Whether histone acetylation is a cause or consequence of transcription is debated. One model suggests that transcription promotes...
2.
Prus G, Satpathy S, Weinert B, Narita T, Choudhary C
Cell
. 2024 Apr;
187(11):2875-2892.e21.
PMID: 38626770
Ubiquitylation regulates most proteins and biological processes in a eukaryotic cell. However, the site-specific occupancy (stoichiometry) and turnover rate of ubiquitylation have not been quantified. Here we present an integrated...
3.
Suryo Rahmanto A, Blum C, Scalera C, Heidelberger J, Mesitov M, Horn-Ghetko D, et al.
Mol Cell
. 2023 Nov;
83(23):4272-4289.e10.
PMID: 37951215
Reactive aldehydes are produced by normal cellular metabolism or after alcohol consumption, and they accumulate in human tissues if aldehyde clearance mechanisms are impaired. Their toxicity has been attributed to...
4.
Aich M, Ansari A, Ding L, Iesmantavicius V, Paul D, Choudhary C, et al.
Cell Rep
. 2023 Sep;
42(10):113177.
PMID: 37751355
Embryonic stem cells (ESCs) can undergo lineage-specific differentiation, giving rise to different cell types that constitute an organism. Although roles of transcription factors and chromatin modifiers in these cells have...
5.
Narita T, Higashijima Y, Kilic S, Liebner T, Walter J, Choudhary C
Nat Genet
. 2023 Apr;
55(4):679-692.
PMID: 37024579
Chromatin features are widely used for genome-scale mapping of enhancers. However, discriminating active enhancers from other cis-regulatory elements, predicting enhancer strength and identifying their target genes is challenging. Here we...
6.
Lin Y, Major J, Liebner T, Hourani Z, Travers J, Wennersten S, et al.
J Clin Invest
. 2022 May;
132(10).
PMID: 35575093
Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic...
7.
Hahn M, Covarrubias-Pinto A, Herhaus L, Satpathy S, Klann K, Boyle K, et al.
Proc Natl Acad Sci U S A
. 2021 May;
118(19).
PMID: 33947818
is an intracellular pathogen of a substantial global health concern. In order to identify key players involved in infection, we performed a global host phosphoproteome analysis subsequent to bacterial infection....
8.
Narita T, Ito S, Higashijima Y, Chu W, Neumann K, Walter J, et al.
Mol Cell
. 2021 Mar;
81(10):2166-2182.e6.
PMID: 33765415
The metazoan-specific acetyltransferase p300/CBP is involved in activating signal-induced, enhancer-mediated transcription of cell-type-specific genes. However, the global kinetics and mechanisms of p300/CBP activity-dependent transcription activation remain poorly understood. We performed...
9.
Nakamura K, Kustatscher G, Alabert C, Hodl M, Forne I, Volker-Albert M, et al.
Mol Cell
. 2021 Jan;
81(5):1084-1099.e6.
PMID: 33450211
Cells have evolved an elaborate DNA repair network to ensure complete and accurate DNA replication. Defects in these repair machineries can fuel genome instability and drive carcinogenesis while creating vulnerabilities...
10.
Sedlackova H, Rask M, Gupta R, Choudhary C, Somyajit K, Lukas J
Nature
. 2020 Oct;
587(7833):297-302.
PMID: 33087936
Minichromosome maintenance proteins (MCMs) are DNA-dependent ATPases that bind to replication origins and license them to support a single round of DNA replication. A large excess of MCM2-7 assembles on...