Willem B van Ham
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Explore the profile of Willem B van Ham including associated specialties, affiliations and a list of published articles.
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13
Citations
53
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Recent Articles
1.
van Ham W, Meijboom E, Ligtermoet M, Monshouwer-Kloots J, Te Riele A, Asselbergs F, et al.
Stem Cell Res Ther
. 2024 Dec;
15(1):470.
PMID: 39695883
Introduction: A healthy young woman, age 26 without prior cardiac complications, experienced an out-of-hospital cardiac arrest caused by ventricular fibrillation (VF), which coincided with a fever. Comprehensive diagnostics including echo,...
2.
Li E, Boujeddaine N, Houtman M, Maas R, Sluijter J, Ecker G, et al.
Br J Pharmacol
. 2024 Oct;
182(3):633-650.
PMID: 39419581
Background And Purposes: Reduced inward rectifier potassium channel (K2.1) functioning is associated with heart failure and may cause Andersen-Tawil Syndrome, among others characterized by ventricular arrhythmias. Most heart failure or...
3.
Gladka M, Kohela A, de Leeuw A, Molenaar B, Versteeg D, Kooijman L, et al.
Cardiovasc Res
. 2024 Sep;
120(15):1869-1883.
PMID: 39308239
Aims: Intracellular calcium (Ca2+) overload is known to play a critical role in the development of cardiac dysfunction. Despite the remarkable improvement in managing the progression of heart disease, developing...
4.
van Ham W, Meijboom E, Ligtermoet M, Nikkels P, van Veen T
J Cardiovasc Dev Dis
. 2023 Aug;
10(8).
PMID: 37623366
The development of the normal human heart, ranging from gestational age to the mature adult heart, relies on a very delicate and timely orchestrated order of processes. One of the...
5.
van Ham W, Cornelissen C, Polyakova E, van der Voorn S, Ligtermoet M, Monshouwer-Kloots J, et al.
Int J Mol Sci
. 2023 Mar;
24(6).
PMID: 36982449
Chronic kidney disease (CKD) is represented by a diminished filtration capacity of the kidneys. End-stage renal disease patients need dialysis treatment to remove waste and toxins from the circulation. However,...
6.
Tsui H, van Kampen S, Han S, Meraviglia V, van Ham W, Casini S, et al.
Sci Transl Med
. 2023 Mar;
15(688):eadd4248.
PMID: 36947592
Arrhythmogenic cardiomyopathy (ACM) is an inherited progressive cardiac disease. Many patients with ACM harbor mutations in desmosomal genes, predominantly in plakophilin-2 (). Although the genetic basis of ACM is well...
7.
van Kampen S, Han S, van Ham W, Kyriakopoulou E, Stouthart E, Goversen B, et al.
Stem Cell Reports
. 2023 Mar;
18(3):749-764.
PMID: 36868229
Arrhythmogenic cardiomyopathy (ACM) is an inherited progressive disease characterized by electrophysiological and structural remodeling of the ventricles. However, the disease-causing molecular pathways, as a consequence of desmosomal mutations, are poorly...
8.
van Ham W, Cornelissen C, van Veen T
Acta Physiol (Oxf)
. 2022 Sep;
236(3):e13888.
PMID: 36148604
Chronic kidney disease (CKD) and cardiovascular disease (CVD) have an estimated 700-800 and 523 million cases worldwide, respectively, with CVD being the leading cause of death in CKD patients. The...
9.
van Ham W, Kessler E, Oerlemans M, Handoko M, Sluijter J, van Veen T, et al.
JACC Basic Transl Sci
. 2022 Sep;
7(8):844-857.
PMID: 36061340
At least one-half of the growing heart failure population consists of heart failure with preserved ejection fraction (HFpEF). The limited therapeutic options, the complexity of the syndrome, and many related...
10.
Li E, Loen V, van Ham W, Kool W, van der Heyden M, Takanari H
Front Physiol
. 2022 Feb;
12:812572.
PMID: 35145427
Alteration of the inward rectifier current , carried by K2.1 channels, affects action potential duration, impacts resting membrane stability and associates with cardiac arrhythmias. Congenital and acquired K2.1 malfunction frequently...