Wiebke Janssen
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Explore the profile of Wiebke Janssen including associated specialties, affiliations and a list of published articles.
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24
Citations
355
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Recent Articles
1.
Janssen W, Jensen H, Harth V, Oldenburg M
Inquiry
. 2024 Jan;
61:469580231221288.
PMID: 38240089
Shipping is considered a demanding environment that can significantly impact seafarers' well-being and mental health. This review aims to examine existing literature on the resilience of seafarers, with a focus...
2.
Piel I, Engelen A, Lang D, Schulz S, Gerisch M, Brase C, et al.
Eur J Drug Metab Pharmacokinet
. 2023 Jun;
48(4):411-425.
PMID: 37365440
Background And Objectives: Current anticoagulants pose an increased risk of bleeding. The development of drugs targeting factor XIa, like asundexian, may provide a safer treatment option. A human mass‑balance study...
3.
Nayakanti S, Friedrich A, Sarode P, Jafari L, Maroli G, Boehm M, et al.
Circ Res
. 2023 Apr;
132(11):1468-1485.
PMID: 37042252
Background: The ability of the right ventricle (RV) to adapt to an increased pressure afterload determines survival in patients with pulmonary arterial hypertension. At present, there are no specific treatments...
4.
Janssen W, Schwarz T, Butehorn U, Steinke W, Sandmann S, Lang D, et al.
Xenobiotica
. 2022 May;
52(5):453-462.
PMID: 35616579
Vericiguat is a soluble guanylate cyclase stimulator. The pharmacokinetics, absorption, metabolism, and excretion properties of vericiguat in rats and dogs and the distribution in rats are reported. [C]-labelled vericiguat was...
5.
Nelissen E, Possemis N, van Goethem N, Schepers M, Mulder-Jongen D, Dietz L, et al.
Sci Rep
. 2022 Mar;
12(1):3589.
PMID: 35246566
Soluble guanylate cyclase (sGC) requires a heme-group bound in order to produce cGMP, a second messenger involved in memory formation, while heme-free sGC is inactive. Two compound classes can increase...
6.
Berghausen E, Janssen W, Vantler M, Gnatzy-Feik L, Krause M, Behringer A, et al.
J Clin Invest
. 2021 Oct;
131(19).
PMID: 34596056
Enhanced signaling via RTKs in pulmonary hypertension (PH) impedes current treatment options because it perpetuates proliferation and apoptosis resistance of pulmonary arterial smooth muscle cells (PASMCs). Here, we demonstrated hyperphosphorylation...
7.
Taavitsainen P, Gieschen H, Korjamo T, Kahkonen M, Malmstrom C, Prien O, et al.
Xenobiotica
. 2020 Feb;
50(8):967-979.
PMID: 32003293
1. Darolutamide is a novel selective androgen receptor antagonist consisting of two pharmacologically equipotent diastereoisomers. The absorption, distribution, metabolism and excretion properties of darolutamide in rats are reported.2. Non- or...
8.
Rai N, Veeroju S, Schymura Y, Janssen W, Wietelmann A, Kojonazarov B, et al.
Biomed Res Int
. 2019 Jan;
2018:7491284.
PMID: 30643819
No abstract available.
9.
Rai N, Veeroju S, Schymura Y, Janssen W, Wietelmann A, Kojonazarov B, et al.
Biomed Res Int
. 2018 Mar;
2018:3293584.
PMID: 29511676
Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by remodeling of the pulmonary vasculature and a rise in right ventricular (RV) afterload. The increased RV afterload leads to right...
10.
Luitel H, Sydykov A, Schymura Y, Mamazhakypov A, Janssen W, Pradhan K, et al.
Physiol Rep
. 2017 Mar;
5(6).
PMID: 28330950
Right ventricular (RV) remodeling represents a complex set of functional and structural adaptations in response to chronic pressure or volume overload due to various inborn defects or acquired diseases and...