Ralph T Schermuly
Overview
Explore the profile of Ralph T Schermuly including associated specialties, affiliations and a list of published articles.
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Articles
182
Citations
5793
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Recent Articles
1.
Kelly M, Nikolaev V, Gobejishvili L, Lugnier C, Hesslinger C, Nickolaus P, et al.
Pharmacol Rev
. 2025 Mar;
77(3):100042.
PMID: 40081105
Cyclic nucleotides are synthesized by adenylyl and/or guanylyl cyclase, and downstream of this synthesis, the cyclic nucleotide phosphodiesterase families (PDEs) specifically hydrolyze cyclic nucleotides. PDEs control cyclic adenosine-3',5'monophosphate (cAMP) and...
2.
Seidel L, Thudium J, Smith C, Sapehia V, Sommer N, Wujak M, et al.
Cell Signal
. 2024 Dec;
127:111527.
PMID: 39622428
Pulmonary hypertension (PH) is a general term used to describe high blood pressure in the lungs from any cause. Pulmonary arterial hypertension (PAH) is a progressive, and fatal disease that...
3.
Senescence of lung mesenchymal stem cells of preterm infants by cyclic stretch and hyperoxia via p21
Behnke J, Goetz M, Holzfurtner L, Korte P, Weiss A, Shahzad T, et al.
Am J Physiol Lung Cell Mol Physiol
. 2024 Sep;
327(5):L694-L711.
PMID: 39316679
Phenotype distortion of lung resident mesenchymal stem cells (MSC) in preterm infants is a hallmark event in the pathogenesis of bronchopulmonary dysplasia (BPD). Here, we evaluated the impact of cyclic...
4.
Guignabert C, Aman J, Bonnet S, Dorfmuller P, Olschewski A, Pullamsetti S, et al.
Eur Respir J
. 2024 Aug;
64(4).
PMID: 39209474
In recent years, major advances have been made in the understanding of the cellular and molecular mechanisms driving pulmonary vascular remodelling in various forms of pulmonary hypertension, including pulmonary arterial...
5.
Jurida L, Werner S, Knapp F, Niemann B, Li L, Grun D, et al.
Nat Cardiovasc Res
. 2024 Aug;
3(7):819-840.
PMID: 39196177
The molecular mechanisms of progressive right heart failure are incompletely understood. In this study, we systematically examined transcriptomic changes occurring over months in isolated cardiomyocytes or whole heart tissues from...
6.
Kojonazarov B, Kremer N, Pilz C, Ghofrani H, Weissmann N, Naeije R, et al.
Am J Respir Cell Mol Biol
. 2024 Jul;
71(1):133-135.
PMID: 38949324
No abstract available.
7.
Henneke I, Pilz C, Wilhelm J, Alexopoulos I, Ezaddoustdar A, Mukhametshina R, et al.
Am J Physiol Cell Physiol
. 2024 Apr;
326(6):C1637-C1647.
PMID: 38646782
Bleomycin (BLM)-induced lung injury in mice is a valuable model for investigating the molecular mechanisms that drive inflammation and fibrosis and for evaluating potential therapeutic approaches to treat the disease....
8.
Yalcin B, Macas J, Wiercinska E, Harter P, Fawaz M, Schmachtel T, et al.
Cells
. 2023 Dec;
12(23).
PMID: 38067194
The bone marrow (BM) hematopoietic system (HS) gives rise to blood cells originating from hematopoietic stem cells (HSCs), including megakaryocytes (MKs) and red blood cells (erythrocytes; RBCs). Many steps of...
9.
Eichstaedt C, Bikou O, Sommer N, Schermuly R, Pullamsetti S, Weissmann N, et al.
Pneumologie
. 2023 Nov;
77(11):862-870.
PMID: 37963476
The recently published new European guidelines for diagnosis and treatment of pulmonary hypertension now offer the so far most extensive description of genetic testing and counselling for pulmonary arterial hypertension...
10.
Knight H, Abis G, Kaur M, Green H, Krasemann S, Hartmann K, et al.
Circ Res
. 2023 Nov;
133(12):966-988.
PMID: 37955182
Background: Pulmonary hypertension (PH) is a chronic vascular disease characterized, among other abnormalities, by hyperproliferative smooth muscle cells and a perturbed cellular redox and metabolic balance. Oxidants induce cell cycle...