Wesley L McKeithan
Overview
Explore the profile of Wesley L McKeithan including associated specialties, affiliations and a list of published articles.
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17
Citations
799
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Recent Articles
1.
Stevens A, Harris A, Gerdts J, Kim K, Trentesaux C, Ramirez J, et al.
Nature
. 2022 Dec;
614(7946):144-152.
PMID: 36509107
Cell adhesion molecules are ubiquitous in multicellular organisms, specifying precise cell-cell interactions in processes as diverse as tissue development, immune cell trafficking and the wiring of the nervous system. Here...
2.
Gomez-Galeno J, Okolotowicz K, Johnson M, McKeithan W, Mercola M, Cashman J
Pharmacol Res Perspect
. 2021 Jul;
9(4):e00828.
PMID: 34327875
Prolongation of the cardiac action potential (AP) and early after depolarizations (EADs) are electrical anomalies of cardiomyocytes that can lead to lethal arrhythmias and are potential liabilities for existing drugs...
3.
Johnson M, Gomez-Galeno J, Ryan D, Okolotowicz K, McKeithan W, Sampson K, et al.
Bioorg Med Chem Lett
. 2021 Jun;
46:128162.
PMID: 34062251
In the United States, approximately one million individuals are hospitalized every year for arrhythmias, making arrhythmias one of the top causes of healthcare expenditures. Mexiletine is currently used as an...
4.
Cashman J, Ryan D, McKeithan W, Okolotowicz K, Gomez-Galeno J, Johnson M, et al.
J Med Chem
. 2021 May;
64(9):5384-5403.
PMID: 33942619
Ventricular cardiac arrhythmia (VA) arises in acquired or congenital heart disease. Long QT syndrome type-3 (LQT3) is a congenital form of VA caused by cardiac sodium channel (I) SCN5A mutations...
5.
Cheng J, Tsuda M, Okolotowicz K, Dwyer M, Bushway P, Colas A, et al.
Cell Chem Biol
. 2021 Jan;
28(5):625-635.e5.
PMID: 33503403
Wnt signaling plays a central role in tissue maintenance and cancer. Wnt activates downstream genes through β-catenin, which interacts with TCF/LEF transcription factors. A major question is how this signaling...
6.
Toda S, McKeithan W, Hakkinen T, Lopez P, Klein O, Lim W
Science
. 2020 Oct;
370(6514):327-331.
PMID: 33060357
In metazoan tissues, cells decide their fates by sensing positional information provided by specialized morphogen proteins. To explore what features are sufficient for positional encoding, we asked whether arbitrary molecules...
7.
McKeithan W, Feyen D, Bruyneel A, Okolotowicz K, Ryan D, Sampson K, et al.
Cell Stem Cell
. 2020 Sep;
27(5):813-821.e6.
PMID: 32931730
Modeling cardiac disorders with human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes is a new paradigm for preclinical testing of candidate therapeutics. However, disease-relevant physiological assays can be complex, and the...
8.
Feyen D, McKeithan W, Bruyneel A, Spiering S, Hormann L, Ulmer B, et al.
Cell Rep
. 2020 Jul;
32(3):107925.
PMID: 32697997
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have enormous potential for the study of human cardiac disorders. However, their physiological immaturity severely limits their utility as a model system and their...
9.
Seeger T, Shrestha R, Lam C, Chen C, McKeithan W, Lau E, et al.
Circulation
. 2018 Dec;
139(6):799-811.
PMID: 30586709
Background: Hypertrophic cardiomyopathy (HCM) is frequently caused by mutations in myosin-binding protein C3 ( MYBPC3) resulting in a premature termination codon (PTC). The underlying mechanisms of how PTC mutations in...
10.
Sharma A, McKeithan W, Serrano R, Kitani T, Burridge P, Del Alamo J, et al.
Nat Protoc
. 2018 Nov;
13(12):3018-3041.
PMID: 30413796
Cardiotoxicity has historically been a major cause of drug removal from the pharmaceutical market. Several chemotherapeutic compounds have been noted for their propensities to induce dangerous cardiac-specific side effects such...