Arne A N Bruyneel
Overview
Explore the profile of Arne A N Bruyneel including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
363
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0
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Recent Articles
1.
Serrano R, Feyen D, Bruyneel A, Hnatiuk A, Vu M, Amatya P, et al.
Cell Stem Cell
. 2022 Dec;
30(1):86-95.e4.
PMID: 36563695
Drug safety initiatives have endorsed human iPSC-derived cardiomyocytes (hiPSC-CMs) as an in vitro model for predicting drug-induced cardiac arrhythmia. However, the extent to which human-defined features of in vitro arrhythmia...
2.
Hnatiuk A, Bruyneel A, Tailor D, Pandrala M, Dheeraj A, Li W, et al.
Cancer Res
. 2022 Jun;
82(15):2777-2791.
PMID: 35763671
Significance: Newly developed ponatinib analogs retain antitumor efficacy but elicit significantly decreased cardiotoxicity, representing a therapeutic opportunity for safer CML treatment.
3.
Perea-Gil I, Seeger T, Bruyneel A, Termglinchan V, Monte E, Lim E, et al.
Eur Heart J
. 2022 Jun;
43(36):3477-3489.
PMID: 35728000
Aims: Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. Despite significant progress in understanding the genetic aetiologies of DCM, the molecular mechanisms underlying the pathogenesis of familial...
4.
Lopez C, Al-Siddiqi H, Purnama U, Iftekhar S, Bruyneel A, Kerr M, et al.
Sci Rep
. 2021 Apr;
11(1):7802.
PMID: 33833285
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) enable human cardiac cells to be studied in vitro, although they use glucose as their primary metabolic substrate and do not recapitulate the...
5.
Cheng J, Tsuda M, Okolotowicz K, Dwyer M, Bushway P, Colas A, et al.
Cell Chem Biol
. 2021 Jan;
28(5):625-635.e5.
PMID: 33503403
Wnt signaling plays a central role in tissue maintenance and cancer. Wnt activates downstream genes through β-catenin, which interacts with TCF/LEF transcription factors. A major question is how this signaling...
6.
McKeithan W, Feyen D, Bruyneel A, Okolotowicz K, Ryan D, Sampson K, et al.
Cell Stem Cell
. 2020 Sep;
27(5):813-821.e6.
PMID: 32931730
Modeling cardiac disorders with human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes is a new paradigm for preclinical testing of candidate therapeutics. However, disease-relevant physiological assays can be complex, and the...
7.
Feyen D, McKeithan W, Bruyneel A, Spiering S, Hormann L, Ulmer B, et al.
Cell Rep
. 2020 Jul;
32(3):107925.
PMID: 32697997
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have enormous potential for the study of human cardiac disorders. However, their physiological immaturity severely limits their utility as a model system and their...
8.
Bruyneel A, Colas A, Karakikes I, Mercola M
PLoS One
. 2019 Dec;
14(12):e0226694.
PMID: 31877162
Gene editing strategies, such as zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9), are revolutionizing biology. However, quantitative and sensitive detection of...
9.
Hurtado C, Safarova A, Smith M, Chung R, Bruyneel A, Gomez-Galeno J, et al.
Sci Rep
. 2019 Jul;
9(1):10811.
PMID: 31346210
NOTCH plays a pivotal role during normal development and in congenital disorders and cancer. γ-secretase inhibitors are commonly used to probe NOTCH function, but also block processing of numerous other...
10.
Bruyneel A, McKeithan W, Feyen D, Mercola M
Curr Cardiol Rep
. 2018 May;
20(7):57.
PMID: 29802473
Purpose Of Review: Cardiovascular disease is the leading contributor to mortality and morbidity. Many deaths of heart failure patients can be attributed to sudden cardiac death due primarily to ventricular...