Wen-Hsuan Wu
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Explore the profile of Wen-Hsuan Wu including associated specialties, affiliations and a list of published articles.
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29
Citations
753
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Recent Articles
1.
Lopes da Costa B, Quinn P, Wu W, Liu S, Nolan N, Demirkol A, et al.
Cell Biosci
. 2024 May;
14(1):64.
PMID: 38773556
Background: Retinitis pigmentosa (RP) is a genetically heterogeneous group of degenerative disorders causing progressive vision loss due to photoreceptor death. RP affects other retinal cells, including the retinal pigment epithelium...
2.
Nolan N, Cui X, Robbings B, Demirkol A, Pandey K, Wu W, et al.
Cell Rep Med
. 2024 Mar;
5(4):101459.
PMID: 38518771
Retinitis pigmentosa (RP) is one of the most common forms of hereditary neurodegeneration. It is caused by one or more of at least 3,100 mutations in over 80 genes that...
3.
Tseng Y, Chiu Y, Pham V, Wu W, Le-Vu T, Wang C, et al.
ACS Sens
. 2024 Jan;
9(1):455-463.
PMID: 38234004
Selective detection of biomarkers at low concentrations in blood is crucial for the clinical diagnosis of many diseases but remains challenging. In this work, we aimed to develop an ultrasensitive...
4.
Chang Y, Rakshit S, Huang C, Wu W
PeerJ
. 2023 Sep;
11:e15907.
PMID: 37719117
Background: In this research, we propose probabilistic approaches to identify pairwise patterns of species co-occurrence by using presence-absence maps only. In particular, the two-by-two contingency table constructed from a presence-absence...
5.
Wu W, Tso A, Breazzano M, Jenny L, Levi S, Tsang S, et al.
Methods Mol Biol
. 2022 Dec;
2560:303-311.
PMID: 36481906
Due to the clinically established safety and efficacy profile of recombinant adeno-associated viral (rAAV) vectors, they are considered the "go to" vector for retinal gene therapy. Design of a rAAV-mediated...
6.
Wu W, Tsai Y, Huang I, Cheng C, Hsu C, Cui X, et al.
Mol Ther
. 2022 Feb;
30(4):1407-1420.
PMID: 35150888
Mutations in rhodopsin (RHO) are the most common causes of autosomal dominant retinitis pigmentosa (adRP), accounting for 20% to 30% of all cases worldwide. However, the high degree of genetic...
7.
Tsai Y, Li Y, Ryu J, Su P, Cheng C, Wu W, et al.
Am J Hum Genet
. 2021 Apr;
108(5):903-918.
PMID: 33909993
Macular degeneration (MD) is characterized by the progressive deterioration of the macula and represents one of the most prevalent causes of blindness worldwide. Abnormal intracellular accumulation of lipid droplets and...
8.
Sancho-Pelluz J, Cui X, Lee W, Tsai Y, Wu W, Justus S, et al.
Cell Mol Life Sci
. 2019 Apr;
76(18):3657-3665.
PMID: 30976840
D190N, a missense mutation in rhodopsin, causes photoreceptor degeneration in patients with autosomal dominant retinitis pigmentosa (adRP). Two competing hypotheses have been developed to explain why D190N rod photoreceptors degenerate:...
9.
Zhang L, Cui X, Jauregui R, Park K, Justus S, Tsai Y, et al.
Mol Ther
. 2018 Jul;
26(8):1953-1964.
PMID: 30001913
Microglia cells (MGCs) play a key role in scavenging pathogens and phagocytosing cellular debris in the central nervous system and retina. Their activation, however, contributes to the progression of multiple...
10.
Tsai Y, Wu W, Lee T, Wu W, Xu C, Park K, et al.
Ophthalmology
. 2018 May;
125(9):1421-1430.
PMID: 29759820
Purpose: To develop a universal gene therapy to overcome the genetic heterogeneity in retinitis pigmentosa (RP) resulting from mutations in rhodopsin (RHO). Design: Experimental study for a combination gene therapy...