Wen-Hsuan Chang
Overview
Explore the profile of Wen-Hsuan Chang including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
15
Citations
592
Followers
0
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Recent Articles
1.
Hung S, Linares G, Chang W, Eoh Y, Krishnan G, Mendonca S, et al.
Cell
. 2023 Feb;
186(4):786-802.e28.
PMID: 36754049
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results from many diverse genetic causes. Although therapeutics specifically targeting known causal mutations may rescue individual types of ALS, these...
2.
Linares G, Li Y, Chang W, Rubin-Sigler J, Mendonca S, Hong S, et al.
Cell Stem Cell
. 2023 Feb;
30(2):171-187.e14.
PMID: 36736291
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by many diverse genetic etiologies. Although therapeutics that specifically target causal mutations may rescue individual types of ALS, such approaches...
3.
Chang W, Liu Y, Hammes E, Bryant K, Cerione R, Antonyak M
J Biol Chem
. 2022 Dec;
299(2):102842.
PMID: 36581205
The small GTPase KRAS is frequently mutated in pancreatic cancer and its cooperation with the transcription factor MYC is essential for malignant transformation. The key to oncogenic KRAS and MYC...
4.
Sun S, Chang C, Zhan Z, Chang W, Chen Y, Dong Y
Int J Chron Obstruct Pulmon Dis
. 2021 Oct;
16:2721-2733.
PMID: 34621122
Background: Several observational studies have found that statins may materially decrease the risk of chronic obstructive pulmonary disease (COPD) exacerbations. However, most of these studies used a prevalent user, non-user...
5.
Chang W, Nguyen T, Hsu C, Bryant K, Kim H, Ying H, et al.
Cancer Lett
. 2021 Jun;
517:66-77.
PMID: 34111513
Mutations in KRAS frequently occur in human cancer and are especially prevalent in pancreatic ductal adenocarcinoma (PDAC), where they have been shown to promote aggressive phenotypes. However, targeting this onco-protein...
6.
Bakkar N, Starr A, Rabichow B, Lorenzini I, McEachin Z, Kraft R, et al.
Neurobiol Dis
. 2020 Dec;
149:105228.
PMID: 33359139
Disruption in copper homeostasis causes a number of cognitive and motor deficits. Wilson's disease and Menkes disease are neurodevelopmental disorders resulting from mutations in the copper transporters ATP7A and ATP7B,...
7.
Chang W, Cerione R, Antonyak M
Methods Mol Biol
. 2020 Aug;
2174:143-170.
PMID: 32813249
Extracellular vesicles (EVs) produced by cancer cells function as a unique form of intercellular communication that can promote cell growth and survival, help shape the tumor microenvironment, and increase invasive...
8.
Lan W, Lin S, Kao C, Chang W, Yeh H, Chang H, et al.
Proc Natl Acad Sci U S A
. 2020 May;
117(21):11257-11264.
PMID: 32404423
Dmc1 recombinases are essential to homologous recombination in meiosis. Here, we studied the kinetics of the nucleoprotein filament assembly of Dmc1 using single-molecule tethered particle motion experiments and in vitro...
9.
Chen C, Lanz R, Walkey C, Chang W, Lu W, Johnson D
Cell Rep
. 2018 Aug;
24(7):1852-1864.
PMID: 30110641
RNA polymerase (pol) III transcribes a variety of small untranslated RNAs involved in transcription, RNA processing, and translation. RNA pol III and its components are altered in various human developmental...
10.
Shi Y, Lin S, Staats K, Li Y, Chang W, Hung S, et al.
Nat Med
. 2018 Feb;
24(3):313-325.
PMID: 29400714
An intronic GGGGCC repeat expansion in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic mechanism of this repeat remains unclear....