Wen-Hsien Liu
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Explore the profile of Wen-Hsien Liu including associated specialties, affiliations and a list of published articles.
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28
Citations
495
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Recent Articles
21.
Liu W, Kang S, Huang Z, Wu C, Jin H, Maine C, et al.
J Exp Med
. 2016 Aug;
213(9):1901-19.
PMID: 27481129
MicroRNA (miRNA) deficiency impairs the generation of T follicular helper (Tfh) cells, but the contribution of individual miRNAs to this phenotype remains poorly understood. In this study, we performed deep...
22.
Hsiao H, Hsu T, Liu W, Hsieh W, Chou T, Wu Y, et al.
Nat Commun
. 2015 Feb;
6:6353.
PMID: 25695215
Application of regulatory T cells (Tregs) in transplantation, autoimmunity and allergy has been extensively explored, but how Foxp3 and Treg stability is regulated in vivo is incompletely understood. Here, we...
23.
Hsu T, Hsiao H, Wu P, Liu W, Lai M
J Immunol
. 2014 Jul;
193(4):1672-80.
PMID: 25000980
The generation of T cell anergy is associated with upregulation of ubiquitin E3 ligases including Casitas B-lineage lymphoma (Cbl-b), Itch, gene related to anergy in lymphocyte, and deltex1 (DTX1). These...
24.
MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways
Jin H, Oda H, Lai M, Skalsky R, Bethel K, Shepherd J, et al.
EMBO J
. 2013 Aug;
32(17):2377-91.
PMID: 23921550
MicroRNAs (miRNAs) have been broadly implicated in cancer, but their exact function and mechanism in carcinogenesis remain poorly understood. Elevated miR-17~92 expression is frequently found in human cancers, mainly due...
25.
Kang S, Liu W, Lu P, Jin H, Lim H, Shepherd J, et al.
Nat Immunol
. 2013 Jul;
14(8):849-57.
PMID: 23812097
Follicular helper T cells (T(FH) cells) provide critical help to B cells during humoral immune responses. Here we report that mice with T cell-specific deletion of the miR-17∼92 family of...
26.
Hsiao H, Liu W, Wang C, Lo Y, Wu Y, Jiang S, et al.
Immunity
. 2009 Jul;
31(1):72-83.
PMID: 19592273
The molecular process underlying T cell anergy is incompletely understood. Deltex1 (DTX1) is a Notch target with unknown physiological function. Here we show that Dtx1 was a transcription target of...
27.
Liu W, Hsiao H, Tsou W, Lai M
EMBO J
. 2007 Feb;
26(6):1660-9.
PMID: 17318174
The physiological activity of Notch is a function of its ability to increase survival in many cell types. Several pathways have been shown to contribute to the survival effect of...
28.
Liu W, Lai M
Mol Cell Biol
. 2005 Feb;
25(4):1367-78.
PMID: 15684388
Deltex is known as a Notch signal mediator, but its physiological action mechanism is poorly understood. Here we identified a new regulatory role of Deltex in T-cell activation. Deltex expression...